GON1_LITCT
ID GON1_LITCT Reviewed; 90 AA.
AC Q90Y63;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH I;
DE AltName: Full=LHRH I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GAP1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor;
GN Name=gnrh1; Synonyms=gnrh;
OS Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=8400 {ECO:0000312|EMBL:AAL05972.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Forebrain;
RX PubMed=11170016;
RX DOI=10.1002/1097-010x(20010215)289:3<190::aid-jez6>3.0.co;2-e;
RA Wang L., Yoo M.S., Kang H.M., Im W.B., Choi H.S., Bogerd J., Kwon H.B.;
RT "Cloning and characterization of cDNAs encoding the GnRH1 and GnRH2
RT precursors from bullfrog (Rana catesbeiana).";
RL J. Exp. Zool. 289:190-201(2001).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC {ECO:0000255|RuleBase:RU000635, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P45656}.
CC -!- TISSUE SPECIFICITY: Forebrain. {ECO:0000269|PubMed:11170016}.
CC -!- DEVELOPMENTAL STAGE: Expressed at significantly higher levels during
CC post-breeding. Not expressed in pituitary.
CC {ECO:0000269|PubMed:11170016}.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; AF188754; AAL05972.1; -; mRNA.
DR AlphaFoldDB; Q90Y63; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; NAS:UniProtKB.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; NAS:UniProtKB.
DR GO; GO:0000003; P:reproduction; NAS:UniProtKB.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..90
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012544"
FT PEPTIDE 25..34
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012545"
FT PEPTIDE 38..86
FT /note="GnRH-associated peptide 1"
FT /evidence="ECO:0000250"
FT /id="PRO_0000012546"
FT MOD_RES 25
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 34
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 90 AA; 10291 MW; 317203B4E3DA2FE7 CRC64;
MSRHVTVVLL LAIVLLLSSH MIHGQHWSYG LRPGGKREVE SLQESYAEVP NEVSFTELQH
LECSIPQNRI SLVRDALMNW LEGENARKKI
