GON1_MACMU
ID GON1_MACMU Reviewed; 67 AA.
AC P55247;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor; Fragment;
GN Name=GNRH1; Synonyms=GNRH, LHRH;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus;
RX PubMed=7545971; DOI=10.1159/000126769;
RA Ma Y.J., Costa M.E., Ojeda S.R.;
RT "Developmental expression of the genes encoding transforming growth factor
RT alpha and its receptor in the hypothalamus of female rhesus macaques.";
RL Neuroendocrinology 60:346-359(1994).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC secretion of both luteinizing and follicle-stimulating hormones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: [Gonadoliberin-1]: The precursor is cleaved by ACE, which removes
CC the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone.
CC The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.
CC {ECO:0000250|UniProtKB:P01148}.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; S75918; AAB33096.1; -; mRNA.
DR PIR; I78541; I78541.
DR RefSeq; NP_001182365.1; NM_001195436.1.
DR AlphaFoldDB; P55247; -.
DR SMR; P55247; -.
DR STRING; 9544.ENSMMUP00000032173; -.
DR GeneID; 613033; -.
DR KEGG; mcc:613033; -.
DR CTD; 2796; -.
DR eggNOG; ENOG502S8C8; Eukaryota.
DR HOGENOM; CLU_2412553_0_0_1; -.
DR InParanoid; P55247; -.
DR OrthoDB; 1556205at2759; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IBA:GO_Central.
DR GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL <1..5
FT /evidence="ECO:0000250"
FT CHAIN 6..>67
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012398"
FT PEPTIDE 6..15
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012399"
FT PEPTIDE 19..>67
FT /note="GnRH-associated peptide 1"
FT /id="PRO_0000012400"
FT SITE 8..9
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 8
FT /note="Appears to be essential for biological activity"
FT /evidence="ECO:0000250"
FT SITE 10..11
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 12..13
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 15..16
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT MOD_RES 6
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT MOD_RES 15
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 67
SQ SEQUENCE 67 AA; 7573 MW; 505394DAA261A3F2 CRC64;
EGCSSQHWSY GLRPGGKRDA ENLMDSFQEI VKEVGQLAET QHFECTMHQP RSPLQDLKGA
LESLIEE
