ID   GON1_MESAU              Reviewed;          63 AA.
AC   O09163;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Progonadoliberin-1;
DE   AltName: Full=Progonadoliberin I;
DE   Contains:
DE     RecName: Full=Gonadoliberin-1;
DE     AltName: Full=Gonadoliberin I;
DE     AltName: Full=Gonadotropin-releasing hormone I;
DE              Short=GnRH-I;
DE     AltName: Full=Luliberin I;
DE     AltName: Full=Luteinizing hormone-releasing hormone I;
DE              Short=LH-RH I;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 1;
DE     AltName: Full=GnRH-associated peptide I;
DE   Flags: Precursor; Fragment;
GN   Name=GNRH1; Synonyms=GNRH, LHRH;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Jansen H.T., Stevens P.J., Zeitler P., Lehman M.N.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: [Gonadoliberin-1]: The precursor is cleaved by ACE, which removes
CC       the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone.
CC       The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.
CC       {ECO:0000250|UniProtKB:P01148}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U91938; AAB51302.1; -; mRNA.
DR   AlphaFoldDB; O09163; -.
DR   STRING; 10036.XP_005075289.1; -.
DR   eggNOG; ENOG502S8C8; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IEA:InterPro.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   InterPro; IPR004079; Gonadoliberin_I_precursor.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PRINTS; PR01541; GONADOLIBRNI.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   CHAIN           1..>63
FT                   /note="Progonadoliberin-1"
FT                   /id="PRO_0000012401"
FT   PEPTIDE         1..10
FT                   /note="Gonadoliberin-1"
FT                   /id="PRO_0000012402"
FT   PEPTIDE         14..>63
FT                   /note="GnRH-associated peptide 1"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000012403"
FT   SITE            3..4
FT                   /note="Cleavage; by ACE"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   SITE            3
FT                   /note="Appears to be essential for biological activity"
FT                   /evidence="ECO:0000250"
FT   SITE            5..6
FT                   /note="Cleavage; by ACE"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   SITE            7..8
FT                   /note="Cleavage; by ACE"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   SITE            10..11
FT                   /note="Cleavage; by ACE"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   MOD_RES         10
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         63
SQ   SEQUENCE   63 AA;  7370 MW;  FC94995676F77180 CRC64;
     QHWSYGLRPG GKRNAERLGD SFQEMDKEVD QLAEPQHLEC TVHWPRSPLR DLRGVLESLI
     EEE