ID   GON1_MORSA              Reviewed;          95 AA.
AC   O73812;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Progonadoliberin-1;
DE   AltName: Full=Progonadoliberin I;
DE   Contains:
DE     RecName: Full=Gonadoliberin-1;
DE     AltName: Full=Gonadoliberin I;
DE     AltName: Full=Gonadotropin-releasing hormone I;
DE              Short=GnRH-I;
DE     AltName: Full=Luliberin I;
DE     AltName: Full=Luteinizing hormone-releasing hormone I;
DE              Short=LH-RH I;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 1;
DE     AltName: Full=GnRH-associated peptide I;
DE   Flags: Precursor;
GN   Name=gnrh1;
OS   Morone saxatilis (Striped bass) (Perca saxatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Morone.
OX   NCBI_TaxID=34816;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9845669; DOI=10.1677/jme.0.0210277;
RA   Chow M.M., Kight K.E., Gothilf Y., Alok D., Stubblefield J., Zohar Y.;
RT   "Multiple GnRHs present in a teleost species are encoded by separate genes:
RT   analysis of the sbGnRH and cGnRH-II genes from the striped bass, Morone
RT   saxatilis.";
RL   J. Mol. Endocrinol. 21:277-289(1998).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF056314; AAD03817.1; -; Genomic_DNA.
DR   AlphaFoldDB; O73812; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..95
FT                   /note="Progonadoliberin-1"
FT                   /id="PRO_0000012435"
FT   PEPTIDE         23..32
FT                   /note="Gonadoliberin-1"
FT                   /id="PRO_0000012436"
FT   PEPTIDE         36..95
FT                   /note="GnRH-associated peptide 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000012437"
FT   MOD_RES         23
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         32
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   95 AA;  10411 MW;  980C6988FC279BFC CRC64;
     MAPQTFALWL LLVGTLLGQG CCQHWSYGLS PGGKRELDGL SETLGNQIVG GFPHVETPCR
     VLGCAVESPF PKIYRMKGFL DAVTDRENGP RTYKK