GON1_MOUSE
ID GON1_MOUSE Reviewed; 90 AA.
AC P13562;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=Prolactin release-inhibiting factor 1;
DE AltName: Full=Prolactin release-inhibiting factor I;
DE Flags: Precursor;
GN Name=Gnrh1; Synonyms=Gnrh;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3024317; DOI=10.1126/science.3024317;
RA Mason A.J., Hayflick J.S., Zoeller R.T., Young W.S. III, Phillips H.S.,
RA Nikolics K., Seeburg P.H.;
RT "A deletion truncating the gonadotropin-releasing hormone gene is
RT responsible for hypogonadism in the hpg mouse.";
RL Science 234:1366-1371(1986).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC secretion of both luteinizing and follicle-stimulating hormones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: [Gonadoliberin-1]: The precursor is cleaved by ACE, which removes
CC the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone.
CC The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.
CC {ECO:0000250|UniProtKB:P01148}.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; M14872; AAA37717.1; -; Genomic_DNA.
DR CCDS; CCDS27231.1; -.
DR PIR; A47578; RHMSG.
DR RefSeq; NP_032171.1; NM_008145.3.
DR AlphaFoldDB; P13562; -.
DR SMR; P13562; -.
DR IntAct; P13562; 3.
DR STRING; 10090.ENSMUSP00000106724; -.
DR PaxDb; P13562; -.
DR PRIDE; P13562; -.
DR Antibodypedia; 5376; 471 antibodies from 33 providers.
DR DNASU; 14714; -.
DR Ensembl; ENSMUST00000111095; ENSMUSP00000106724; ENSMUSG00000015812.
DR Ensembl; ENSMUST00000223951; ENSMUSP00000153071; ENSMUSG00000015812.
DR GeneID; 14714; -.
DR KEGG; mmu:14714; -.
DR UCSC; uc007ulh.2; mouse.
DR CTD; 2796; -.
DR MGI; MGI:95789; Gnrh1.
DR VEuPathDB; HostDB:ENSMUSG00000015812; -.
DR eggNOG; ENOG502S8C8; Eukaryota.
DR GeneTree; ENSGT00390000008225; -.
DR HOGENOM; CLU_2412553_0_0_1; -.
DR InParanoid; P13562; -.
DR OMA; ISSGQHW; -.
DR OrthoDB; 1556205at2759; -.
DR PhylomeDB; P13562; -.
DR TreeFam; TF330934; -.
DR Reactome; R-MMU-375281; Hormone ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 14714; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Gnrh1; mouse.
DR PRO; PR:P13562; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; P13562; protein.
DR Bgee; ENSMUSG00000015812; Expressed in primary oocyte and 89 other tissues.
DR ExpressionAtlas; P13562; baseline and differential.
DR GO; GO:0043679; C:axon terminus; ISO:MGI.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005798; C:Golgi-associated vesicle; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:1990008; C:neurosecretory vesicle; ISO:MGI.
DR GO; GO:0043204; C:perikaryon; ISO:MGI.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; ISO:MGI.
DR GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR GO; GO:0030238; P:male sex determination; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0033087; P:negative regulation of immature T cell proliferation; ISO:MGI.
DR GO; GO:2001223; P:negative regulation of neuron migration; IDA:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR GO; GO:2000354; P:regulation of ovarian follicle development; IMP:MGI.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR GO; GO:0045471; P:response to ethanol; IDA:MGI.
DR GO; GO:0048545; P:response to steroid hormone; IMP:MGI.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT CHAIN 22..90
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012404"
FT PEPTIDE 22..31
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012405"
FT PEPTIDE 35..90
FT /note="Prolactin release-inhibiting factor 1"
FT /id="PRO_0000012406"
FT SITE 24..25
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 24
FT /note="Appears to be essential for biological activity"
FT SITE 26..27
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 28..29
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 31..32
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT MOD_RES 31
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 90 AA; 10337 MW; 1C0766FA4826E4D9 CRC64;
MILKLMAGIL LLTVCLEGCS SQHWSYGLRP GGKRNTEHLV ESFQEMGKEV DQMAEPQHFE
CTVHWPRSPL RDLRGALESL IEEEARQKKM
