GON1_ORYLA
ID GON1_ORYLA Reviewed; 91 AA.
AC Q9DGC8; Q8JIQ7;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Medaka-type gonadotropin-releasing hormone;
DE Short=mdGnRH;
DE AltName: Full=Progonadoliberin I;
DE AltName: Full=mfGnRH;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor;
GN Name=gnrh1;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000312|EMBL:BAB16303.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000312|EMBL:BAB16303.1};
RX PubMed=11006121; DOI=10.1006/bbrc.2000.3476;
RA Okubo K., Amano M., Yoshiura Y., Suetake H., Aida K.;
RT "A novel form of gonadotropin-releasing hormone in the medaka, Oryzias
RT latipes.";
RL Biochem. Biophys. Res. Commun. 276:298-303(2000).
RN [2] {ECO:0000312|EMBL:BAC06421.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Himedaka {ECO:0000269|PubMed:12137956}, and
RC HNI {ECO:0000312|EMBL:BAC06421.1};
RX PubMed=12137956; DOI=10.1016/s0378-1119(02)00724-2;
RA Okubo K., Mitani H., Naruse K., Kondo M., Shima A., Tanaka M., Asakawa S.,
RA Shimizu N., Yoshiura Y., Aida K.;
RT "Structural characterization of GnRH loci in the medaka genome.";
RL Gene 293:181-189(2002).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC {ECO:0000250|UniProtKB:P51918}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P51918}.
CC -!- TISSUE SPECIFICITY: Expressed in the cell bodies of a cluster of
CC neurons in the preoptic region. {ECO:0000269|PubMed:11006121}.
CC -!- MISCELLANEOUS: Teleost species possess three paralogous GnRHs: mdGnRH
CC and cGnRH-II have been identified in tetrapods; sGnRH has no tetrapod
CC ortholog and is thought to be a duplication of cGnRH-II.
CC {ECO:0000303|PubMed:12137956}.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; AB041333; BAB16303.1; -; mRNA.
DR EMBL; AB041336; BAC06419.1; -; Genomic_DNA.
DR EMBL; AB074499; BAC06421.1; -; Genomic_DNA.
DR PIR; JC7393; JC7393.
DR RefSeq; NP_001098169.1; NM_001104699.1.
DR AlphaFoldDB; Q9DGC8; -.
DR STRING; 8090.ENSORLP00000017869; -.
DR Ensembl; ENSORLT00000017870; ENSORLP00000017869; ENSORLG00000014247.
DR GeneID; 100049266; -.
DR KEGG; ola:100049266; -.
DR CTD; 2796; -.
DR eggNOG; ENOG502TDRE; Eukaryota.
DR GeneTree; ENSGT00760000119772; -.
DR HOGENOM; CLU_2319525_0_0_1; -.
DR InParanoid; Q9DGC8; -.
DR OMA; AKIYRMK; -.
DR OrthoDB; 1556205at2759; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Proteomes; UP000265180; Unplaced.
DR Proteomes; UP000265200; Unplaced.
DR Bgee; ENSORLG00000014247; Expressed in brain and 2 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR002012; GnRH.
DR PROSITE; PS00473; GNRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..91
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012438"
FT PEPTIDE 22..31
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012439"
FT PEPTIDE 35..91
FT /note="GnRH-associated peptide 1"
FT /id="PRO_0000012440"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 31
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
FT CONFLICT 8
FT /note="P -> L (in Ref. 2; BAC06421)"
FT /evidence="ECO:0000305"
FT CONFLICT 54
FT /note="T -> A (in Ref. 2; BAC06421)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 91 AA; 10307 MW; A00F2BED6FD6E0B5 CRC64;
MVVKTWMPWL LVSSVLSQGC CQHWSFGLSP GGKRELKYFP NTLENQIRLL NSNTPCSDLS
HLEESSLAKI YRIKGLLGSV TEAKNGYRTY K
