ID   GON1_PETMA              Reviewed;          10 AA.
AC   P04378;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Gonadoliberin-1;
DE   AltName: Full=Gonadoliberin I;
DE   AltName: Full=Gonadotropin-releasing hormone I;
DE            Short=GnRH-I;
DE   AltName: Full=Luliberin I;
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   GLY-10.
RC   TISSUE=Brain;
RX   PubMed=3514603; DOI=10.1016/s0021-9258(19)89177-9;
RA   Sherwood N.M., Sower S.A., Marshak D.R., Fraser B.A., Brownstein M.J.;
RT   "Primary structure of gonadotropin-releasing hormone from lamprey brain.";
RL   J. Biol. Chem. 261:4812-4819(1986).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   PIR; A01412; RHLMGS.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Gonadoliberin-1"
FT                   /id="PRO_0000043959"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3514603"
FT   MOD_RES         10
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:3514603"
SQ   SEQUENCE   10 AA;  1244 MW;  1E4B36237B1735AB CRC64;
     QHYSLEWKPG