GON1_PIG
ID GON1_PIG Reviewed; 91 AA.
AC P49921;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor;
GN Name=GNRH1; Synonyms=GNRH;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus;
RA Weesner G.D., Matteri R.L., Becker B.A.;
RL Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 24-33, PYROGLUTAMATE FORMATION AT GLN-24, AND AMIDATION
RP AT GLY-33.
RX PubMed=4946067; DOI=10.1016/0006-291x(71)90623-1;
RA Baba Y., Matsuo H., Schally A.V.;
RT "Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation
RT of the proposed structure by conventional sequential analyses.";
RL Biochem. Biophys. Res. Commun. 44:459-463(1971).
RN [3]
RP SYNTHESIS OF GONADOLIBERIN.
RX PubMed=4942726; DOI=10.1016/0006-291x(71)90491-8;
RA Matsuo H., Arimura A., Nair R.M.G., Schally A.V.;
RT "Synthesis of the porcine LH- and FSH-releasing hormone by the solid-phase
RT method.";
RL Biochem. Biophys. Res. Commun. 45:822-827(1971).
RN [4]
RP SYNTHESIS OF GONADOLIBERIN.
RX PubMed=4946275; DOI=10.1016/0006-291x(71)90844-8;
RA Baba Y., Arimura A., Schally A.V.;
RT "On the tryptophan residue in porcine LH and FSH-releasing hormone.";
RL Biochem. Biophys. Res. Commun. 45:483-487(1971).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC secretion of both luteinizing and follicle-stimulating hormones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: [Gonadoliberin-1]: The precursor is cleaved by ACE, which removes
CC the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone.
CC The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.
CC {ECO:0000250|UniProtKB:P01148}.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; L32864; AAA31066.1; -; mRNA.
DR PIR; A01411; RHPGG.
DR RefSeq; NP_999439.1; NM_214274.1.
DR RefSeq; XP_005670498.1; XM_005670441.2.
DR AlphaFoldDB; P49921; -.
DR SMR; P49921; -.
DR STRING; 9823.ENSSSCP00000010305; -.
DR PaxDb; P49921; -.
DR Ensembl; ENSSSCT00000010581; ENSSSCP00000010305; ENSSSCG00000009651.
DR Ensembl; ENSSSCT00030012984; ENSSSCP00030005842; ENSSSCG00030009477.
DR Ensembl; ENSSSCT00035011319; ENSSSCP00035003870; ENSSSCG00035009035.
DR Ensembl; ENSSSCT00040106151; ENSSSCP00040048746; ENSSSCG00040076253.
DR Ensembl; ENSSSCT00045041719; ENSSSCP00045028941; ENSSSCG00045024471.
DR Ensembl; ENSSSCT00050082815; ENSSSCP00050035545; ENSSSCG00050060777.
DR Ensembl; ENSSSCT00065039511; ENSSSCP00065016723; ENSSSCG00065029275.
DR Ensembl; ENSSSCT00070046735; ENSSSCP00070039423; ENSSSCG00070023452.
DR GeneID; 397516; -.
DR KEGG; ssc:397516; -.
DR CTD; 2796; -.
DR VGNC; VGNC:88548; GNRH1.
DR eggNOG; ENOG502S8C8; Eukaryota.
DR GeneTree; ENSGT00390000008225; -.
DR HOGENOM; CLU_2412553_0_0_1; -.
DR InParanoid; P49921; -.
DR OMA; ISSGQHW; -.
DR OrthoDB; 1556205at2759; -.
DR TreeFam; TF330934; -.
DR Reactome; R-SSC-375281; Hormone ligand-binding receptors.
DR Reactome; R-SSC-416476; G alpha (q) signalling events.
DR Proteomes; UP000008227; Chromosome 14.
DR Proteomes; UP000314985; Chromosome 14.
DR Bgee; ENSSSCG00000009651; Expressed in caecum and 28 other tissues.
DR ExpressionAtlas; P49921; baseline.
DR Genevisible; P49921; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IBA:GO_Central.
DR GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:4946067"
FT CHAIN 24..91
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012407"
FT PEPTIDE 24..33
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012408"
FT PEPTIDE 34..91
FT /note="GnRH-associated peptide 1"
FT /id="PRO_0000012409"
FT SITE 26..27
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 26
FT /note="Appears to be essential for biological activity"
FT SITE 28..29
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 30..31
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 33..34
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:4946067"
FT MOD_RES 33
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:4946067"
SQ SEQUENCE 91 AA; 10090 MW; 8340474F32DDAA99 CRC64;
MEPIPKLLAG LLLLTLCVVG CSSQHWSYGL RPGGKRNAEN VIDSFQEMAK EVARLAEPQR
FECTAHQPRS PLRDLKGALE SLIEEETGQK T
