GON1_RAT
ID GON1_RAT Reviewed; 92 AA.
AC P07490;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=Prolactin release-inhibiting factor 1;
DE AltName: Full=Prolactin release-inhibiting factor I;
DE Flags: Precursor;
GN Name=Gnrh1; Synonyms=Gnrh;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2867548; DOI=10.1073/pnas.83.1.179;
RA Adelman J.P., Mason A.J., Hayflick J.S., Seeburg P.H.;
RT "Isolation of the gene and hypothalamic cDNA for the common precursor of
RT gonadotropin-releasing hormone and prolactin release-inhibiting factor in
RT human and rat.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:179-183(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2476669; DOI=10.1210/mend-3-8-1257;
RA Bond C.T., Hayflick J.S., Seeburg P.H., Adelman J.P.;
RT "The rat gonadotropin-releasing hormone: SH locus: structure and
RT hypothalamic expression.";
RL Mol. Endocrinol. 3:1257-1262(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus;
RX PubMed=1468115; DOI=10.1007/bf00711545;
RA Maier C.C., Marchetti B., Leboeuf R.D., Blalock J.E.;
RT "Thymocytes express a mRNA that is identical to hypothalamic luteinizing
RT hormone-releasing hormone mRNA.";
RL Cell. Mol. Neurobiol. 12:447-454(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-47.
RC TISSUE=Heart;
RX PubMed=3547652; DOI=10.1126/science.3547652;
RA Adelman J.P., Bond C.T., Douglass J., Herbert E.;
RT "Two mammalian genes transcribed from opposite strands of the same DNA
RT locus.";
RL Science 235:1514-1517(1987).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC secretion of both luteinizing and follicle-stimulating hormones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Central nervous system.
CC -!- PTM: [Gonadoliberin-1]: The precursor is cleaved by ACE, which removes
CC the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone.
CC The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.
CC {ECO:0000250|UniProtKB:P01148}.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; S50870; AAB24572.1; -; mRNA.
DR EMBL; M12579; AAA41263.1; -; mRNA.
DR EMBL; M31670; AAA41264.1; -; Genomic_DNA.
DR EMBL; M15527; AAA42141.1; ALT_SEQ; mRNA.
DR EMBL; M15529; AAA42139.1; -; mRNA.
DR EMBL; M15528; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A40147; RHRTG.
DR RefSeq; NP_036899.1; NM_012767.2.
DR AlphaFoldDB; P07490; -.
DR STRING; 10116.ENSRNOP00000018006; -.
DR BindingDB; P07490; -.
DR PaxDb; P07490; -.
DR GeneID; 25194; -.
DR KEGG; rno:25194; -.
DR UCSC; RGD:2720; rat.
DR CTD; 2796; -.
DR RGD; 2720; Gnrh1.
DR VEuPathDB; HostDB:ENSRNOG00000066847; -.
DR eggNOG; ENOG502S8C8; Eukaryota.
DR HOGENOM; CLU_2412553_0_0_1; -.
DR InParanoid; P07490; -.
DR OMA; ISSGQHW; -.
DR PhylomeDB; P07490; -.
DR TreeFam; TF330934; -.
DR Reactome; R-RNO-375281; Hormone ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P07490; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000013441; Expressed in pancreas and 19 other tissues.
DR Genevisible; P07490; RN.
DR GO; GO:0043679; C:axon terminus; IDA:RGD.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:RGD.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0005798; C:Golgi-associated vesicle; IDA:RGD.
DR GO; GO:0005739; C:mitochondrion; IDA:RGD.
DR GO; GO:0043005; C:neuron projection; IDA:RGD.
DR GO; GO:1990008; C:neurosecretory vesicle; IDA:RGD.
DR GO; GO:0043204; C:perikaryon; IDA:RGD.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IDA:RGD.
DR GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0044849; P:estrous cycle; IEP:RGD.
DR GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR GO; GO:0030238; P:male sex determination; IMP:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
DR GO; GO:0033087; P:negative regulation of immature T cell proliferation; IMP:RGD.
DR GO; GO:2001223; P:negative regulation of neuron migration; ISO:RGD.
DR GO; GO:0030728; P:ovulation; TAS:RGD.
DR GO; GO:0042698; P:ovulation cycle; IEP:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR GO; GO:2000354; P:regulation of ovarian follicle development; ISO:RGD.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR GO; GO:0031960; P:response to corticosteroid; IEP:RGD.
DR GO; GO:0045471; P:response to ethanol; ISO:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR GO; GO:0035864; P:response to potassium ion; IEP:RGD.
DR GO; GO:1990637; P:response to prolactin; IEP:RGD.
DR GO; GO:0034695; P:response to prostaglandin E; IEP:RGD.
DR GO; GO:0048545; P:response to steroid hormone; ISO:RGD.
DR GO; GO:0033574; P:response to testosterone; IEP:RGD.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT CHAIN 24..92
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012410"
FT PEPTIDE 24..33
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012411"
FT PEPTIDE 37..92
FT /note="Prolactin release-inhibiting factor 1"
FT /id="PRO_0000012412"
FT SITE 26..27
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 26
FT /note="Appears to be essential for biological activity"
FT SITE 28..29
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 30..31
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT SITE 33..34
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P01148"
FT MOD_RES 33
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 92 AA; 10500 MW; 494B5C64DA8A3EB3 CRC64;
METIPKLMAA VVLLTVCLEG CSSQHWSYGL RPGGKRNTEH LVDSFQEMGK EEDQMAEPQN
FECTVHWPRS PLRDLRGALE RLIEEEAGQK KM
