GON1_SHEEP
ID GON1_SHEEP Reviewed; 61 AA.
AC Q28588;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor; Fragment;
GN Name=GNRH1; Synonyms=GNRH, LHRH;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-61.
RC STRAIN=Western range; TISSUE=Hypothalamus;
RA Rodriguez R.E., Wise M.E.;
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 1-10, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION
RP AT GLY-10.
RX PubMed=4550508; DOI=10.1073/pnas.69.1.278;
RA Burgus R., Butcher M., Amoss M., Ling N., Monahan M., Rivier J.,
RA Fellows R., Blackwell R., Vale W., Guillemin R.;
RT "Primary structure of the ovine hypothalamic luteinizing hormone-releasing
RT factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-
RT decapeptide-Edman degradation).";
RL Proc. Natl. Acad. Sci. U.S.A. 69:278-282(1972).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC secretion of both luteinizing and follicle-stimulating hormones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; U02517; AAA03433.1; -; mRNA.
DR PIR; A93780; RHSHG.
DR PDB; 1YY1; NMR; -; A=2-10.
DR PDBsum; 1YY1; -.
DR AlphaFoldDB; Q28588; -.
DR SMR; Q28588; -.
DR STRING; 9940.ENSOARP00000010607; -.
DR eggNOG; ENOG502S8C8; Eukaryota.
DR EvolutionaryTrace; Q28588; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IEA:InterPro.
DR GO; GO:0046880; P:regulation of follicle-stimulating hormone secretion; IMP:AgBase.
DR GO; GO:0033684; P:regulation of luteinizing hormone secretion; IMP:AgBase.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Amidation; Cleavage on pair of basic residues;
KW Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted.
FT CHAIN 1..>61
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012413"
FT PEPTIDE 1..10
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012414"
FT PEPTIDE 14..>61
FT /note="GnRH-associated peptide 1"
FT /id="PRO_0000012415"
FT SITE 3
FT /note="Appears to be essential for biological activity"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:4550508"
FT MOD_RES 10
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:4550508"
FT NON_TER 1
FT NON_TER 61
FT STRAND 6..9
FT /evidence="ECO:0007829|PDB:1YY1"
SQ SEQUENCE 61 AA; 6828 MW; 63962A1AE319B8F0 CRC64;
QHWSYGLRPG GKRNAKNVID SFQEIAKEVD QPVEPKCCGC IVHQSHSPLR DLKAALESLI
E
