ID   GON1_TUPBE              Reviewed;          92 AA.
AC   Q95335;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Progonadoliberin-1;
DE   AltName: Full=Progonadoliberin I;
DE   Contains:
DE     RecName: Full=Gonadoliberin-1;
DE     AltName: Full=Gonadoliberin I;
DE     AltName: Full=Gonadotropin-releasing hormone I;
DE              Short=GnRH-I;
DE     AltName: Full=Luliberin I;
DE     AltName: Full=Luteinizing hormone-releasing hormone I;
DE              Short=LH-RH I;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 1;
DE     AltName: Full=GnRH-associated peptide I;
DE   Flags: Precursor;
GN   Name=GNRH1; Synonyms=GNRH;
OS   Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=37347;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=8921350; DOI=10.1006/gcen.1996.0135;
RA   Kasten T.L., White S.A., Norton T.T., Bond C.T., Adelman J.P.,
RA   Fernald R.D.;
RT   "Characterization of two new preproGnRH mRNAs in the tree shrew: first
RT   direct evidence for mesencephalic GnRH gene expression in a placental
RT   mammal.";
RL   Gen. Comp. Endocrinol. 104:7-19(1996).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U63326; AAB16837.1; -; mRNA.
DR   AlphaFoldDB; Q95335; -.
DR   SMR; Q95335; -.
DR   HOGENOM; CLU_2412553_0_0_1; -.
DR   TreeFam; TF330934; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IEA:InterPro.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   InterPro; IPR004079; Gonadoliberin_I_precursor.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PRINTS; PR01541; GONADOLIBRNI.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..92
FT                   /note="Progonadoliberin-1"
FT                   /id="PRO_0000012416"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-1"
FT                   /id="PRO_0000012417"
FT   PEPTIDE         37..92
FT                   /note="GnRH-associated peptide 1"
FT                   /id="PRO_0000012418"
FT   SITE            26
FT                   /note="Appears to be essential for biological activity"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  10197 MW;  4FDBF2C58CF5F63B CRC64;
     MELVPKFLAG LILLTLCVGG CYAQHWSYGL RPGGKRNAEN LIDSFQEIAK EADQLAEPQH
     FECTISQPRS PLRALKGALE SLIEEETGQK KI