ID   GON1_VERMO              Reviewed;          96 AA.
AC   Q8UW80;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Progonadoliberin-1;
DE   AltName: Full=Progonadoliberin I;
DE   AltName: Full=Seabream-type gonadotropin-releasing hormone;
DE            Short=SbGnRH;
DE   Contains:
DE     RecName: Full=Gonadoliberin-1;
DE     AltName: Full=Gonadoliberin I;
DE     AltName: Full=Gonadotropin-releasing hormone I;
DE              Short=GnRH-I;
DE     AltName: Full=Luliberin I;
DE     AltName: Full=Luteinizing hormone-releasing hormone I;
DE              Short=LH-RH I;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 1;
DE     AltName: Full=GnRH-associated peptide I;
DE   Flags: Precursor;
GN   Name=gnrh1;
OS   Verasper moseri (Barfin flounder).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae; Verasper.
OX   NCBI_TaxID=98923;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=12093120; DOI=10.1016/s0016-6480(02)00008-4;
RA   Amano M., Takahashi A., Yamanome T., Okubo K., Aida K., Yamamori K.;
RT   "Molecular cloning of three cDNAs encoding different GnRHs in the brain of
RT   barfin flounder.";
RL   Gen. Comp. Endocrinol. 126:325-333(2002).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Preoptic area of the brain.
CC       {ECO:0000269|PubMed:12093120}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AB066360; BAB83984.1; -; mRNA.
DR   AlphaFoldDB; Q8UW80; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; ISS:UniProtKB.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR004079; Gonadoliberin_I_precursor.
DR   PRINTS; PR01541; GONADOLIBRNI.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..96
FT                   /note="Progonadoliberin-1"
FT                   /id="PRO_0000012447"
FT   PEPTIDE         27..36
FT                   /note="Gonadoliberin-1"
FT                   /id="PRO_0000012448"
FT   PEPTIDE         40..96
FT                   /note="GnRH-associated peptide 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000012449"
FT   MOD_RES         27
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         36
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   96 AA;  10560 MW;  FA3202565EA00DCC CRC64;
     MHRKMAVKTL SVWLLLVGTL VPQHCCQHWS YGLSPGGKRQ LDSLSQTLGN VVEEFPRVDS
     PCSVLGGAEE SPFAGIYRMK GFLGSITDRG NRTQNI