ID   GON1_XENLA              Reviewed;          89 AA.
AC   P45656;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Progonadoliberin-1;
DE   AltName: Full=Progonadoliberin I;
DE   Contains:
DE     RecName: Full=Gonadoliberin-1;
DE     AltName: Full=Gonadoliberin I;
DE     AltName: Full=Gonadotropin-releasing hormone I;
DE              Short=GnRH-I;
DE     AltName: Full=Luliberin I;
DE     AltName: Full=Luteinizing hormone-releasing hormone I;
DE              Short=LH-RH I;
DE   Contains:
DE     RecName: Full=Gonadotropin-releasing hormone-associated peptide;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 1;
DE     AltName: Full=GnRH-associated peptide I;
DE   Flags: Precursor;
GN   Name=gnrh1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AMIDATION AT GLY-33, TISSUE SPECIFICITY,
RP   AND DEVELOPMENTAL STAGE.
RC   TISSUE=Forebrain;
RX   PubMed=8137750; DOI=10.1210/endo.134.4.8137750;
RA   Hayes W.P., Wray S., Battey J.F.;
RT   "The frog gonadotropin-releasing hormone-I (GnRH-I) gene has a mammalian-
RT   like expression pattern and conserved domains in GnRH-associated peptide,
RT   but brain onset is delayed until metamorphosis.";
RL   Endocrinology 134:1835-1844(1994).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the forebrain from larval stages.
CC       {ECO:0000269|PubMed:8137750}.
CC   -!- DEVELOPMENTAL STAGE: First expressed in late larvae (stages 62-64).
CC       Also expressed in adults. {ECO:0000269|PubMed:8137750}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; L28040; AAA49728.1; -; Genomic_DNA.
DR   PIR; I51423; I51423.
DR   RefSeq; XP_018107225.1; XM_018251736.1.
DR   AlphaFoldDB; P45656; -.
DR   GeneID; 108710621; -.
DR   CTD; 108710621; -.
DR   Xenbase; XB-GENE-6500232; gnrh1.L.
DR   OMA; ISSGQHW; -.
DR   OrthoDB; 1556205at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 108710621; Expressed in brain and 10 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IEA:InterPro.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   InterPro; IPR004079; Gonadoliberin_I_precursor.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PRINTS; PR01541; GONADOLIBRNI.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..89
FT                   /note="Progonadoliberin-1"
FT                   /id="PRO_0000012422"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-1"
FT                   /id="PRO_0000012423"
FT   PEPTIDE         37..89
FT                   /note="Gonadotropin-releasing hormone-associated peptide"
FT                   /id="PRO_0000012424"
FT   PEPTIDE         37..85
FT                   /note="GnRH-associated peptide 1"
FT                   /id="PRO_0000012425"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:8137750"
SQ   SEQUENCE   89 AA;  10246 MW;  6F4F36FBAE0D4284 CRC64;
     MKAFPTFALL FLVLLFSAHV SDAQHWSYGL RPGGKRDTES LQDMYHETPN EVALFPELER
     LECSVPQSRL NVLRGALMNW LEGENRKKI