ID   GON2A_CARAU             Reviewed;          86 AA.
AC   P51924;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Progonadoliberin IIA;
DE   Contains:
DE     RecName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide IIA;
DE   Flags: Precursor;
GN   Name=gnrh2a; Synonyms=gnrh2;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8729938; DOI=10.1006/gcen.1996.0031;
RA   Lin X.-W., Peter R.E.;
RT   "Expression of salmon gonadotropin-releasing hormone (GnRH) and chicken
RT   GnRH-II precursor messenger ribonucleic acids in the brain and ovary of
RT   goldfish.";
RL   Gen. Comp. Endocrinol. 101:282-296(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-57, AND TISSUE SPECIFICITY.
RC   STRAIN=Comet, and Common; TISSUE=Liver;
RX   PubMed=9289408; DOI=10.1006/gcen.1997.6920;
RA   Lin X.-W., Peter R.E.;
RT   "Cloning and expression pattern of a second [His5Trp7Tyr8]gonadotropin-
RT   releasing hormone (chicken GnRH-H-II) mRNA in goldfish: evidence for two
RT   distinct genes.";
RL   Gen. Comp. Endocrinol. 107:262-272(1997).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Olfactory bulbs, hypothalamus and telencephalon,
CC       midbrain and posterior brain areas. {ECO:0000269|PubMed:9289408}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U30386; AAC59858.1; -; mRNA.
DR   EMBL; U40568; AAB87138.1; -; Genomic_DNA.
DR   AlphaFoldDB; P51924; -.
DR   Ensembl; ENSCART00000028729; ENSCARP00000027397; ENSCARG00000012201.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..86
FT                   /note="Progonadoliberin IIA"
FT                   /id="PRO_0000012468"
FT   PEPTIDE         25..34
FT                   /note="Gonadoliberin II"
FT                   /id="PRO_0000012469"
FT   PEPTIDE         38..86
FT                   /note="GnRH-associated peptide IIA"
FT                   /id="PRO_0000012470"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         34
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   86 AA;  9770 MW;  31488ED8EC9D8D54 CRC64;
     MVHICRLFVV MGMLLCLSAQ FASSQHWSHG WYPGGKREID VYDSSEVSGE IKLCEAGKCS
     YLRPQGRNIL KTILLDAIIR DSQKRK