ID   GON2B_CARAU             Reviewed;          86 AA.
AC   O42471;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Progonadoliberin IIB;
DE   Contains:
DE     RecName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide IIB;
DE   Flags: Precursor;
GN   Name=gnrh2b;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Comet, and Common; TISSUE=Liver;
RX   PubMed=9289408; DOI=10.1006/gcen.1997.6920;
RA   Lin X.-W., Peter R.E.;
RT   "Cloning and expression pattern of a second [His5Trp7Tyr8]gonadotropin-
RT   releasing hormone (chicken GnRH-H-II) mRNA in goldfish: evidence for two
RT   distinct genes.";
RL   Gen. Comp. Endocrinol. 107:262-272(1997).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Olfactory bulbs, hypothalamus and telencephalon,
CC       midbrain and posterior brain areas. {ECO:0000269|PubMed:9289408}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U40567; AAB86989.1; -; mRNA.
DR   EMBL; U40665; AAB86990.1; -; Genomic_DNA.
DR   AlphaFoldDB; O42471; -.
DR   Ensembl; ENSCART00000119380; ENSCARP00000106890; ENSCARG00000054777.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..86
FT                   /note="Progonadoliberin IIB"
FT                   /id="PRO_0000012471"
FT   PEPTIDE         25..34
FT                   /note="Gonadoliberin II"
FT                   /id="PRO_0000012472"
FT   PEPTIDE         38..86
FT                   /note="GnRH-associated peptide IIB"
FT                   /id="PRO_0000012473"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         34
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   86 AA;  9917 MW;  AC1778CE75C1C313 CRC64;
     MVHICRLFVV MGMLMFLSVQ FASSQHWSHG WYPGGKREID VYDPSEVSEE IKLCNAGKCS
     FLIPQGRNIL KTILLDALTR DFQKRK