ID   GON2_CHEPR              Reviewed;          10 AA.
AC   P80678;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   29-SEP-2021, entry version 60.
DE   RecName: Full=Gonadoliberin-2;
DE   AltName: Full=Gonadoliberin II;
DE   AltName: Full=Gonadotropin-releasing hormone II;
DE            Short=GnRH-II;
DE   AltName: Full=Luliberin II;
OS   Chelyosoma productum (Solitary ascidian).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Corellidae; Chelyosoma.
OX   NCBI_TaxID=71177;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND MASS SPECTROMETRY.
RX   PubMed=8816823; DOI=10.1073/pnas.93.19.10461;
RA   Powell J.F.F., Reska-Skinner S.M., Prakash M.O., Fischer W.H., Park M.,
RA   Rivier J.E., Craig A.G., Mackie G.O., Sherwood N.M.;
RT   "Two new forms of gonadotropin-releasing hormone in a protochordate and the
RT   evolutionary implications.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:10461-10464(1996).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: GNRH neurons lie within blood sinuses close to the
CC       gonoducts and gonads in both juveniles and adults, implying that the
CC       neuropeptide is released into the bloodstream.
CC   -!- MASS SPECTROMETRY: Mass=1117.52; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:8816823};
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000043957"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:8816823"
FT   MOD_RES         10
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        6
FT                   /note="Interchain"
SQ   SEQUENCE   10 AA;  1135 MW;  284B38D1EEB735A3 CRC64;
     QHWSLCHAPG