ID   GON2_CLUPA              Reviewed;          10 AA.
AC   P68075; P20408; P37043; P81750;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   29-SEP-2021, entry version 36.
DE   RecName: Full=Gonadoliberin-2;
DE   AltName: Full=Gonadoliberin II;
DE   AltName: Full=Gonadotropin-releasing hormone II;
DE            Short=GnRH-II;
DE   AltName: Full=Luliberin II;
DE   AltName: Full=Luteinizing hormone-releasing hormone II;
DE            Short=LH-RH II;
GN   Name=gnrh2;
OS   Clupea pallasii (Pacific herring).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei;
OC   Clupeidae; Clupea.
OX   NCBI_TaxID=30724;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Hypothalamus;
RX   PubMed=6427779; DOI=10.1073/pnas.81.12.3874;
RA   Miyamoto K., Hasegawa Y., Nomura M., Igarashi M., Kangawa K., Matsuo H.;
RT   "Identification of the second gonadotropin-releasing hormone in chicken
RT   hypothalamus: evidence that gonadotropin secretion is probably controlled
RT   by two distinct gonadotropin-releasing hormones in avian species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:3874-3878(1984).
RN   [2]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AMIDATION AT GLY-10,
RP   AND FUNCTION.
RC   TISSUE=Brain, and Pituitary;
RX   PubMed=10650929; DOI=10.1210/endo.141.2.7300;
RA   Carolsfeld J., Powell J.F.F., Park M., Fischer W.H., Craig A.G.,
RA   Chang J.P., Rivier J.E., Sherwood N.M.;
RT   "Primary structure and function of three gonadotropin-releasing hormones,
RT   including a novel form, from an ancient teleost, herring.";
RL   Endocrinology 141:505-512(2000).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC       {ECO:0000269|PubMed:10650929}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..10
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000043951"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:10650929"
FT   MOD_RES         10
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:10650929"
SQ   SEQUENCE   10 AA;  1254 MW;  284B2E437871F5A3 CRC64;
     QHWSHGWYPG