GON2_HAPBU
ID GON2_HAPBU Reviewed; 85 AA.
AC P37044; P20408;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Progonadoliberin-2;
DE AltName: Full=Progonadoliberin II;
DE Contains:
DE RecName: Full=Gonadoliberin-2;
DE AltName: Full=Gonadoliberin II;
DE AltName: Full=Gonadotropin-releasing hormone II;
DE Short=GnRH-II;
DE AltName: Full=Luliberin II;
DE AltName: Full=Luteinizing hormone-releasing hormone II;
DE Short=LH-RH II;
DE Contains:
DE RecName: Full=GnRH-associated peptide 2-1;
DE AltName: Full=GnRH-associated peptide II-1;
DE Contains:
DE RecName: Full=GnRH-associated peptide 2-2;
DE AltName: Full=GnRH-associated peptide II-2;
DE Flags: Precursor;
GN Name=gnrh2;
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8108425; DOI=10.1073/pnas.91.4.1423;
RA White S.A., Bond C.T., Francis R.C., Kasten T.L., Fernald R.D.,
RA Adelman J.P.;
RT "A second gene for gonadotropin-releasing hormone: cDNA and expression
RT pattern in the brain.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:1423-1427(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9748399; DOI=10.1006/gcen.1998.7125;
RA White R.B., Fernald R.D.;
RT "Genomic structure and expression sites of three gonadotropin-releasing
RT hormone genes in one species.";
RL Gen. Comp. Endocrinol. 112:17-25(1998).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in only one cell group in the
CC mesencephalon.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; L27435; AAA74993.1; -; mRNA.
DR PIR; A53453; A53453.
DR RefSeq; XP_005918754.1; XM_005918692.1.
DR AlphaFoldDB; P37044; -.
DR STRING; 8153.XP_005918754.1; -.
DR OrthoDB; 1594143at2759; -.
DR Proteomes; UP000264840; Whole Genome Shotgun Assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PROSITE; PS00473; GNRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT CHAIN 24..85
FT /note="Progonadoliberin-2"
FT /id="PRO_0000012480"
FT PEPTIDE 24..33
FT /note="Gonadoliberin-2"
FT /id="PRO_0000012481"
FT PEPTIDE 37..64
FT /note="GnRH-associated peptide 2-1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012482"
FT PEPTIDE 67..85
FT /note="GnRH-associated peptide 2-2"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012483"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P51918"
FT MOD_RES 33
FT /note="Glycine amide"
FT /evidence="ECO:0000250|UniProtKB:P51918"
SQ SEQUENCE 85 AA; 9631 MW; CF8C0EDBF277365F CRC64;
MCVSRLALLL GLLLCVGAQL SFAQHWSHGW YPGGKRELDS FGTSEISEEI KLCEAGECSY
LRPQRRSILR NILLDALARE LQKRK
