GON2_HUMAN
ID GON2_HUMAN Reviewed; 120 AA.
AC O43555; Q14C68; Q14C69; Q9BYN9; Q9BYP0;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Progonadoliberin-2;
DE AltName: Full=Progonadoliberin II;
DE Contains:
DE RecName: Full=Gonadoliberin-2;
DE AltName: Full=Gonadoliberin II;
DE AltName: Full=Gonadotropin-releasing hormone II;
DE Short=GnRH II;
DE AltName: Full=Luliberin II;
DE AltName: Full=Luteinizing hormone-releasing hormone II;
DE Short=LH-RH II;
DE Contains:
DE RecName: Full=GnRH-associated peptide 2;
DE AltName: Full=GnRH-associated peptide II;
DE Flags: Precursor;
GN Name=GNRH2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX PubMed=9419371; DOI=10.1073/pnas.95.1.305;
RA White R.B., Eisen J.A., Kasten T.L., Fernald R.D.;
RT "Second gene for gonadotropin-releasing hormone in humans.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:305-309(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC secretion of both luteinizing and follicle-stimulating hormones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Comment=Experimental confirmation may be lacking for some isoforms.;
CC Name=1;
CC IsoId=O43555-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O43555-2; Sequence=VSP_001825;
CC Name=3;
CC IsoId=O43555-3; Sequence=VSP_001826;
CC -!- TISSUE SPECIFICITY: Midbrain; expressed at significantly higher levels
CC outside the brain (up to 30-fold), particularly in the kidney, bone
CC marrow and prostate.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; AF036329; AAC02980.1; -; Genomic_DNA.
DR EMBL; AF036330; AAC02981.1; -; mRNA.
DR EMBL; AL121905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10559.1; -; Genomic_DNA.
DR EMBL; BC069362; AAH69362.1; -; mRNA.
DR EMBL; BC115399; AAI15400.1; -; mRNA.
DR EMBL; BC115400; AAI15401.1; -; mRNA.
DR CCDS; CCDS13040.1; -. [O43555-1]
DR CCDS; CCDS13041.1; -. [O43555-3]
DR CCDS; CCDS13042.1; -. [O43555-2]
DR RefSeq; NP_001297149.1; NM_001310220.1. [O43555-1]
DR RefSeq; NP_001492.1; NM_001501.1. [O43555-1]
DR RefSeq; NP_847901.1; NM_178331.1. [O43555-3]
DR RefSeq; NP_847902.1; NM_178332.1. [O43555-2]
DR RefSeq; XP_016883312.1; XM_017027823.1. [O43555-3]
DR AlphaFoldDB; O43555; -.
DR BioGRID; 109059; 1.
DR STRING; 9606.ENSP00000245983; -.
DR iPTMnet; O43555; -.
DR PhosphoSitePlus; O43555; -.
DR BioMuta; GNRH2; -.
DR PaxDb; O43555; -.
DR PeptideAtlas; O43555; -.
DR PRIDE; O43555; -.
DR Antibodypedia; 1029; 178 antibodies from 27 providers.
DR DNASU; 2797; -.
DR Ensembl; ENST00000245983.6; ENSP00000245983.2; ENSG00000125787.11. [O43555-1]
DR Ensembl; ENST00000359100.6; ENSP00000352003.2; ENSG00000125787.11. [O43555-3]
DR Ensembl; ENST00000380346.2; ENSP00000369704.2; ENSG00000125787.11. [O43555-2]
DR Ensembl; ENST00000380347.6; ENSP00000369705.2; ENSG00000125787.11. [O43555-3]
DR GeneID; 2797; -.
DR KEGG; hsa:2797; -.
DR MANE-Select; ENST00000359100.6; ENSP00000352003.2; NM_178331.2; NP_847901.1. [O43555-3]
DR UCSC; uc002whp.2; human. [O43555-1]
DR CTD; 2797; -.
DR DisGeNET; 2797; -.
DR GeneCards; GNRH2; -.
DR HGNC; HGNC:4420; GNRH2.
DR HPA; ENSG00000125787; Tissue enhanced (brain).
DR MIM; 602352; gene.
DR neXtProt; NX_O43555; -.
DR OpenTargets; ENSG00000125787; -.
DR PharmGKB; PA28799; -.
DR VEuPathDB; HostDB:ENSG00000125787; -.
DR eggNOG; KOG4691; Eukaryota.
DR GeneTree; ENSGT00390000005119; -.
DR HOGENOM; CLU_175203_0_0_1; -.
DR InParanoid; O43555; -.
DR OMA; WEGRTMA; -.
DR OrthoDB; 1325349at2759; -.
DR PhylomeDB; O43555; -.
DR TreeFam; TF353529; -.
DR PathwayCommons; O43555; -.
DR Reactome; R-HSA-375281; Hormone ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 2797; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; GNRH2; human.
DR GeneWiki; GNRH2; -.
DR GenomeRNAi; 2797; -.
DR Pharos; O43555; Tbio.
DR PRO; PR:O43555; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; O43555; protein.
DR Bgee; ENSG00000125787; Expressed in right lobe of liver and 108 other tissues.
DR Genevisible; O43555; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IBA:GO_Central.
DR GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; TAS:ProtInc.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PROSITE; PS00473; GNRH; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..120
FT /note="Progonadoliberin-2"
FT /id="PRO_0000012456"
FT PEPTIDE 24..33
FT /note="Gonadoliberin-2"
FT /id="PRO_0000012457"
FT PEPTIDE 37..120
FT /note="GnRH-associated peptide 2"
FT /id="PRO_0000012458"
FT REGION 23..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 33
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
FT VAR_SEQ 52..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_001825"
FT VAR_SEQ 52..58
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_001826"
FT VARIANT 16
FT /note="A -> V (in dbSNP:rs6051545)"
FT /id="VAR_053109"
SQ SEQUENCE 120 AA; 12918 MW; D58CDA14B6D6FB8D CRC64;
MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGRALDTAAG
SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA RTLLTAAREP RPAPPSSNKV
