GON2_HYDCO
ID GON2_HYDCO Reviewed; 10 AA.
AC P68076; P20408; P37043; P81750;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 29-SEP-2021, entry version 37.
DE RecName: Full=Gonadoliberin-2;
DE AltName: Full=Gonadoliberin II;
DE AltName: Full=Gonadotropin-releasing hormone II;
DE Short=GnRH-II;
DE AltName: Full=Luliberin II;
DE AltName: Full=Luteinizing hormone-releasing hormone II;
DE Short=LH-RH II;
GN Name=gnrh2;
OS Hydrolagus colliei (Spotted ratfish) (Chimaera colliei).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Chimaeridae; Hydrolagus.
OX NCBI_TaxID=7873;
RN [1]
RP PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP GLY-10.
RC TISSUE=Brain;
RX PubMed=1678723; DOI=10.1016/0016-6480(91)90306-q;
RA Lovejoy D.A., Sherwood N.M., Fischer W.H., Jackson B.C., Rivier J.E.,
RA Lee T.;
RT "Primary structure of gonadotropin-releasing hormone from the brain of a
RT holocephalan (ratfish: Hydrolagus colliei).";
RL Gen. Comp. Endocrinol. 82:152-161(1991).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR PIR; A61126; A61126.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR002012; GnRH.
DR Pfam; PF00446; GnRH; 1.
DR PROSITE; PS00473; GNRH; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW Secreted.
FT PEPTIDE 1..10
FT /note="Gonadoliberin-2"
FT /id="PRO_0000043952"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:1678723"
FT MOD_RES 10
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:1678723"
SQ SEQUENCE 10 AA; 1254 MW; 284B2E437871F5A3 CRC64;
QHWSHGWYPG