ID   GON2_MACMU              Reviewed;         114 AA.
AC   O97655; Q9TSI3;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Progonadoliberin II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=GNRH2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   White R.B., Urbanski H.F., Fernald R.D.;
RT   "A second gene for gonadotropin-releasing hormone is expressed in the
RT   rhesus macaque (Abstract #632.18).";
RL   Abstr. - Soc. Neurosci. 24:1609-1609(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-107.
RA   Abler L.A., Sherwood N.M., Grendell R.L., Golos T.G., Terasawa E.;
RT   "cDNA of a second form of luteinizing hormone releasing, chicken LHRH-II,
RT   isolated from the non-human primate brain (Abstract #632.8).";
RL   Abstr. - Soc. Neurosci. 24:1607-1607(1998).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF097356; AAD09106.1; -; mRNA.
DR   EMBL; AF104307; AAD13775.1; -; mRNA.
DR   RefSeq; NP_001029374.1; NM_001034202.1.
DR   AlphaFoldDB; O97655; -.
DR   STRING; 9544.ENSMMUP00000007749; -.
DR   Ensembl; ENSMMUT00000008244; ENSMMUP00000007749; ENSMMUG00000005890.
DR   GeneID; 619516; -.
DR   KEGG; mcc:619516; -.
DR   CTD; 2797; -.
DR   VEuPathDB; HostDB:ENSMMUG00000005890; -.
DR   VGNC; VGNC:73103; GNRH2.
DR   eggNOG; KOG4691; Eukaryota.
DR   GeneTree; ENSGT00390000005119; -.
DR   InParanoid; O97655; -.
DR   Proteomes; UP000006718; Chromosome 10.
DR   Bgee; ENSMMUG00000005890; Expressed in ileum and 13 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IBA:GO_Central.
DR   GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..114
FT                   /note="Progonadoliberin-2"
FT                   /id="PRO_0000012459"
FT   PEPTIDE         25..34
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000012460"
FT   PEPTIDE         38..114
FT                   /note="GnRH-associated peptide 2"
FT                   /id="PRO_0000012461"
FT   REGION          35..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         34
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
FT   CONFLICT        24
FT                   /note="A -> V (in Ref. 2; AAD13775)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="L -> I (in Ref. 2; AAD13775)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="V -> A (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   114 AA;  12533 MW;  8B70D690D5BD5103 CRC64;
     MASSRRGLLL LLMLLTAHPG PSEAQHWSHG WYPGGKRALS SAQDPQNALR PPAGSPAQAT
     YGLPSDALAH LEDSMPWEGR TMAWWSLRRK RYLAQTLLTA AREPRPVPPS SNKV