ID   GON2_MORSA              Reviewed;          85 AA.
AC   O73811;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Progonadoliberin II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH-II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=gnrh2;
OS   Morone saxatilis (Striped bass) (Perca saxatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Morone.
OX   NCBI_TaxID=34816;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9845669; DOI=10.1677/jme.0.0210277;
RA   Chow M.M., Kight K.E., Gothilf Y., Alok D., Stubblefield J., Zohar Y.;
RT   "Multiple GnRHs present in a teleost species are encoded by separate genes:
RT   analysis of the sbGnRH and cGnRH-II genes from the striped bass, Morone
RT   saxatilis.";
RL   J. Mol. Endocrinol. 21:277-289(1998).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF056313; AAD03816.1; -; Genomic_DNA.
DR   AlphaFoldDB; O73811; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..85
FT                   /note="Progonadoliberin-2"
FT                   /id="PRO_0000012484"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000012485"
FT   PEPTIDE         37..85
FT                   /note="GnRH-associated peptide 2"
FT                   /id="PRO_0000012486"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   85 AA;  9673 MW;  F832D5B3BC842C64 CRC64;
     MCVSRLVLLF GLLLCVGAQL SNAQHWSHGW YPGGKRELDS FGTSEISEEI KLCEAGECSY
     LRPQRRNVLR NIILDALARE LQKRK