ID   GON2_ONCMY              Reviewed;          86 AA.
AC   O42241;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Progonadoliberin II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH-II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=gnrh2;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Penlington M.C.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF023618; AAB82559.1; -; mRNA.
DR   RefSeq; NP_001117717.1; NM_001124245.1.
DR   AlphaFoldDB; O42241; -.
DR   GeneID; 100135862; -.
DR   KEGG; omy:100135862; -.
DR   OrthoDB; 1594143at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..86
FT                   /note="Progonadoliberin-2"
FT                   /id="PRO_0000012487"
FT   PEPTIDE         25..34
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000012488"
FT   PEPTIDE         38..86
FT                   /note="GnRH-associated peptide 2"
FT                   /id="PRO_0000012489"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   MOD_RES         34
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
SQ   SEQUENCE   86 AA;  9723 MW;  D6EBD59151DC9915 CRC64;
     MVSVARLVFM LGPLLCLGAQ LSSSQHWSHG WYPGGKRELD SFTTSEISEG IKLCEAEGCS
     YLRPQRRNIL KNVILDALAR EFQKRK