GON2_ORYLA
ID GON2_ORYLA Reviewed; 80 AA.
AC Q9DGC9; Q8JIQ5;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Progonadoliberin-2;
DE AltName: Full=Chicken-type II gonadotropin-releasing hormone;
DE AltName: Full=Progonadoliberin II;
DE AltName: Full=cGnRH-II;
DE Contains:
DE RecName: Full=Gonadoliberin-2;
DE AltName: Full=Gonadoliberin II;
DE AltName: Full=Gonadotropin-releasing hormone II;
DE Short=GnRH II;
DE AltName: Full=Luliberin II;
DE AltName: Full=Luteinizing hormone-releasing hormone II;
DE Short=LH-RH II;
DE Contains:
DE RecName: Full=GnRH-associated peptide 2;
DE AltName: Full=GnRH-associated peptide II;
DE Flags: Precursor;
GN Name=gnrh2;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000312|EMBL:BAB16300.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000312|EMBL:BAB16300.1};
RX PubMed=11006121; DOI=10.1006/bbrc.2000.3476;
RA Okubo K., Amano M., Yoshiura Y., Suetake H., Aida K.;
RT "A novel form of gonadotropin-releasing hormone in the medaka, Oryzias
RT latipes.";
RL Biochem. Biophys. Res. Commun. 276:298-303(2000).
RN [2] {ECO:0000312|EMBL:BAC06423.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Himedaka {ECO:0000269|PubMed:12137956}, and
RC HNI {ECO:0000312|EMBL:BAC06423.1};
RX PubMed=12137956; DOI=10.1016/s0378-1119(02)00724-2;
RA Okubo K., Mitani H., Naruse K., Kondo M., Shima A., Tanaka M., Asakawa S.,
RA Shimizu N., Yoshiura Y., Aida K.;
RT "Structural characterization of GnRH loci in the medaka genome.";
RL Gene 293:181-189(2002).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC {ECO:0000250|UniProtKB:P37044, ECO:0000255|RuleBase:RU000635}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P37044}.
CC -!- TISSUE SPECIFICITY: Expressed in the cell bodies of a cluster of
CC neurons in the midbrain tegmentum. {ECO:0000269|PubMed:11006121}.
CC -!- MISCELLANEOUS: Teleost species possess three paralogous GnRHs: mdGnRH
CC and cGnRH-II have been identified in tetrapods; sGnRH has no tetrapod
CC ortholog and is thought to be a duplication of cGnRH-II.
CC {ECO:0000303|PubMed:12137956}.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000255|RuleBase:RU000635,
CC ECO:0000305}.
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DR EMBL; AB041330; BAB16300.1; -; mRNA.
DR EMBL; AB041334; BAC06417.1; -; Genomic_DNA.
DR EMBL; AB074500; BAC06423.1; -; Genomic_DNA.
DR PIR; JC7394; JC7394.
DR RefSeq; NP_001098141.1; NM_001104671.1.
DR AlphaFoldDB; Q9DGC9; -.
DR SMR; Q9DGC9; -.
DR STRING; 8090.ENSORLP00000010654; -.
DR GeneID; 100049219; -.
DR KEGG; ola:100049219; -.
DR CTD; 2797; -.
DR eggNOG; KOG4691; Eukaryota.
DR InParanoid; Q9DGC9; -.
DR OrthoDB; 1594143at2759; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Chromosome 9.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IBA:GO_Central.
DR GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PROSITE; PS00473; GNRH; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..80
FT /note="Progonadoliberin-2"
FT /id="PRO_0000012490"
FT PEPTIDE 22..31
FT /note="Gonadoliberin-2"
FT /id="PRO_0000012491"
FT PEPTIDE 35..80
FT /note="GnRH-associated peptide 2"
FT /id="PRO_0000012492"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 31
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
FT CONFLICT 50
FT /note="T -> A (in Ref. 2; BAC06423)"
FT /evidence="ECO:0000305"
FT CONFLICT 55
FT /note="Y -> F (in Ref. 2; BAC06423)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="S -> N (in Ref. 2; BAC06423)"
FT /evidence="ECO:0000305"
FT CONFLICT 71
FT /note="A -> T (in Ref. 2; BAC06423)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 80 AA; 9311 MW; CAE8F1B06B9AF26E CRC64;
MSRLVLLLGV LLYVGAQLSQ AQHWSHGWYP GGKRELDSFE VSEEMKLCET GECSYMRPQR
RSFLRNIVLD ALARELQKRK
