ID   GON2_SPAAU              Reviewed;          85 AA.
AC   P51925;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Progonadoliberin II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=gnrh2;
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9843645; DOI=10.1006/gcen.1998.7138;
RA   Holland M.C.H., Gothilf Y., Meiri I., King J.A., Okuzawa K., Elizur A.,
RA   Zohar Y.;
RT   "Levels of the native forms of GnRH in the pituitary of the gilthead
RT   seabream, Sparus aurata, at several characteristic stages of the gonadal
RT   cycle.";
RL   Gen. Comp. Endocrinol. 112:394-405(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-33, PYROGLUTAMATE FORMATION AT GLN-24, AMIDATION AT
RP   GLY-33, AND MASS SPECTROMETRY.
RC   TISSUE=Brain;
RX   PubMed=7991588; DOI=10.1073/pnas.91.25.12081;
RA   Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G.,
RA   Rivier J.E., Lovejoy D.A., Sherwood N.M.;
RT   "Three forms of gonadotropin-releasing hormone characterized from brains of
RT   one species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: [Gonadoliberin-2]: Mass=1236.6; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:7991588};
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U30325; AAA75447.1; -; mRNA.
DR   AlphaFoldDB; P51925; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:7991588"
FT   CHAIN           24..85
FT                   /note="Progonadoliberin-2"
FT                   /id="PRO_0000012496"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000012497"
FT   PEPTIDE         37..85
FT                   /note="GnRH-associated peptide 2"
FT                   /id="PRO_0000012498"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:7991588"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:7991588"
SQ   SEQUENCE   85 AA;  9543 MW;  B53165C1227722CC CRC64;
     MCVSRLVLLL GLLLCVGAQL SNGQHWSHGW YPGGKRELDS FGTSEISEEI KLCEAGECSY
     LTPQRRSVLR NILLDALARE LQKRK