ID   GON2_SUNMU              Reviewed;         110 AA.
AC   O97686;
DT   08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Progonadoliberin II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=GNRH2;
OS   Suncus murinus (Asian house shrew) (Musk shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Soricidae; Crocidurinae; Suncus.
OX   NCBI_TaxID=9378;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   White R.B., Kasten T.L., White S.A., Rissman E.F., Fernald R.D.;
RT   "GnRH-II cDNA expression in the musk shrew.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Midbrain.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF107315; AAD09114.1; -; mRNA.
DR   AlphaFoldDB; O97686; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..110
FT                   /note="Progonadoliberin-2"
FT                   /id="PRO_0000012462"
FT   PEPTIDE         27..36
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000012463"
FT   PEPTIDE         40..110
FT                   /note="GnRH-associated peptide 2"
FT                   /id="PRO_0000012464"
FT   REGION          25..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         36
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
SQ   SEQUENCE   110 AA;  12120 MW;  A8986905FB83D9DB CRC64;
     MASIGQGLVL LLLLLLLTAQ PGPLKAQHWS HGWYPGGKRS PDSPQDPQPA PRFPEGYWLG
     LAAGNPRQST QSLPSKALAP PEDTVSEEAK TMAWWHLQKQ RLIQTLLPRP