ID   GON2_TUPBE              Reviewed;         114 AA.
AC   Q95336;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Progonadoliberin II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=GNRH2;
OS   Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=37347;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=8921350; DOI=10.1006/gcen.1996.0135;
RA   Kasten T.L., White S.A., Norton T.T., Bond C.T., Adelman J.P.,
RA   Fernald R.D.;
RT   "Characterization of two new preproGnRH mRNAs in the tree shrew: first
RT   direct evidence for mesencephalic GnRH gene expression in a placental
RT   mammal.";
RL   Gen. Comp. Endocrinol. 104:7-19(1996).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Midbrain.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U63327; AAB16838.1; -; mRNA.
DR   AlphaFoldDB; Q95336; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..114
FT                   /note="Progonadoliberin-2"
FT                   /id="PRO_0000012465"
FT   PEPTIDE         26..35
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000012466"
FT   PEPTIDE         39..114
FT                   /note="GnRH-associated peptide 2"
FT                   /id="PRO_0000012467"
FT   REGION          22..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         35
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01148"
SQ   SEQUENCE   114 AA;  12123 MW;  680E90E1C6869EC1 CRC64;
     MASSMLGFLL LLLLLMAAHP GPSEAQHWSH GWYPGGKRAS NSPQDPQSAL RPPAPSAAQT
     AHSFRSAALA SPEDSVPWEG RTTAGWSLRR KQHLMRTLLS AAGAPRPAAV PIKP