ID   GON2_VERMO              Reviewed;          85 AA.
AC   Q8UW81;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Chicken-type II gonadotropin-releasing hormone;
DE   AltName: Full=Progonadoliberin II;
DE   AltName: Full=cGnRH-II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH-II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=gnrh2;
OS   Verasper moseri (Barfin flounder).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae; Verasper.
OX   NCBI_TaxID=98923;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAB83983.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain {ECO:0000269|PubMed:12093120};
RX   PubMed=12093120; DOI=10.1016/s0016-6480(02)00008-4;
RA   Amano M., Takahashi A., Yamanome T., Okubo K., Aida K., Yamamori K.;
RT   "Molecular cloning of three cDNAs encoding different GnRHs in the brain of
RT   barfin flounder.";
RL   Gen. Comp. Endocrinol. 126:325-333(2002).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC       {ECO:0000255|RuleBase:RU000635}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|RuleBase:RU000635}.
CC   -!- TISSUE SPECIFICITY: Midbrain tegmentum. {ECO:0000269|PubMed:12093120}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AB066359; BAB83983.1; -; mRNA.
DR   AlphaFoldDB; Q8UW81; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; ISS:UniProtKB.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255, ECO:0000312|EMBL:BAB83983.1"
FT   CHAIN           24..85
FT                   /note="Progonadoliberin-2"
FT                   /id="PRO_0000012450"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-2"
FT                   /id="PRO_0000012451"
FT   PEPTIDE         37..85
FT                   /note="GnRH-associated peptide 2"
FT                   /id="PRO_0000012452"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P51925"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   85 AA;  9593 MW;  73B102A23528AA02 CRC64;
     MCASRLVLLL GLLLCVGAHL SSGQHWSHGW YPGGKRELDS FGTSEISEEI KLCEAGECSY
     LRPQRRNILR NILLDALARE LQKRK