ID   GON3_DICLA              Reviewed;          90 AA.
AC   Q9IA09;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Dicentrarchus labrax (European seabass) (Morone labrax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Dicentrarchus.
OX   NCBI_TaxID=13489;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=11086295;
RX   DOI=10.1002/1096-9861(20000101)429:1<144::aid-cne11>3.0.co;2-b;
RA   Gonzalez-Martinez D., Madigou T., Zmora N., Anglade I., Zanuy S., Zohar Y.,
RA   Elizur A., Munoz-Cueto J.A., Kah O.;
RT   "Differential expression of three different prepro-GnRH (gonadotrophin-
RT   releasing hormone) messengers in the brain of the European sea bass
RT   (Dicentrarchus labrax).";
RL   J. Comp. Neurol. 429:144-155(2001).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF224280; AAF62899.1; -; mRNA.
DR   AlphaFoldDB; Q9IA09; -.
DR   Proteomes; UP000694389; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..90
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012502"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012503"
FT   PEPTIDE         37..82
FT                   /note="GnRH-associated peptide 3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000012504"
FT   REGION          56..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   90 AA;  10154 MW;  B06A7BA413930C67 CRC64;
     MEANSRVMVR VLLLALVVQV TLSQHWSYGW LPGGKRSVGE LEATIRMMGT GEVVSLPEEA
     SAQTQERLRP YNVINDDSSH FDRKKRSPNK