ID   GON3_HAPBU              Reviewed;          90 AA.
AC   P45652;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1944299; DOI=10.1210/mend-5-7-931;
RA   Bond C.T., Francis R.C., Fernald R.D., Adelman J.P.;
RT   "Characterization of complementary DNA encoding the precursor for
RT   gonadotropin-releasing hormone and its associated peptide from a teleost
RT   fish.";
RL   Mol. Endocrinol. 5:931-937(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9748399; DOI=10.1006/gcen.1998.7125;
RA   White R.B., Fernald R.D.;
RT   "Genomic structure and expression sites of three gonadotropin-releasing
RT   hormone genes in one species.";
RL   Gen. Comp. Endocrinol. 112:17-25(1998).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed only in the terminal nerve nucleus of the
CC       telencephalon.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF076963; AAC27718.1; -; Genomic_DNA.
DR   PIR; A23735; A23735.
DR   RefSeq; NP_001273267.1; NM_001286338.1.
DR   RefSeq; XP_014191848.1; XM_014336362.1.
DR   AlphaFoldDB; P45652; -.
DR   STRING; 8153.XP_005914221.1; -.
DR   Ensembl; ENSHBUT00000023858; ENSHBUP00000015568; ENSHBUG00000017482.
DR   GeneID; 102307577; -.
DR   CTD; 360141; -.
DR   GeneTree; ENSGT00390000009274; -.
DR   OMA; ATIRMMD; -.
DR   OrthoDB; 1556205at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..90
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012505"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012506"
FT   PEPTIDE         37..82
FT                   /note="GnRH-associated peptide 3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000012507"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P51918"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P51918"
SQ   SEQUENCE   90 AA;  10096 MW;  B36362E9F4A53A4E CRC64;
     MEAGSRVIMQ VLLLALVVQV TLSQHWSYGW LPGGKRSVGE LEATIRMMGT GGVVSLPDEA
     NAQIQERLRP YNIINDDSSH FDRKKRFPNN