ID   GON3_ONCMA              Reviewed;          82 AA.
AC   P30973;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Oncorhynchus masou (Cherry salmon) (Masu salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8020;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1515027; DOI=10.1677/jme.0.0090073;
RA   Suzuki M., Hyodo S., Kobayashi M., Aida K., Urano A.;
RT   "Characterization and localization of mRNA encoding the salmon-type
RT   gonadotrophin-releasing hormone precursor of the masu salmon.";
RL   J. Mol. Endocrinol. 9:73-82(1992).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; D10946; BAA01740.1; -; mRNA.
DR   EMBL; S44614; AAB63599.1; -; mRNA.
DR   PIR; I51180; I51180.
DR   AlphaFoldDB; P30973; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..82
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012508"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012509"
FT   PEPTIDE         37..82
FT                   /note="GnRH-associated peptide 3"
FT                   /id="PRO_0000012510"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
SQ   SEQUENCE   82 AA;  9184 MW;  7595A0B8964B9B86 CRC64;
     MDLSSKTVVQ VVMLALIAQV TFSQHWSYGW LPGGKRSVGE LEATIRMMDT GGVMALPEET
     GAHIPERLRP YDVMSKKRMP HK