ID   GON3_ONCMY              Reviewed;          74 AA.
AC   P55246;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor; Fragment;
GN   Name=gnrh3;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Muscle;
RA   Klungland H., Anderson O., Alestroem P.;
RT   "The salmon gonadotrophin-releasing hormone encoding gene in salmonids.";
RL   Mol. Mar. Biol. Biotechnol. 1:420-425(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-65.
RX   PubMed=1308825;
RA   Alestroem P., Kisen G., Klungland H., Andersen O.;
RT   "Fish gonadotropin-releasing hormone gene and molecular approaches for
RT   control of sexual maturation: development of a transgenic fish model.";
RL   Mol. Mar. Biol. Biotechnol. 1:376-379(1992).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X79710; CAA56149.1; -; Genomic_DNA.
DR   EMBL; S65569; AAD13966.1; -; Genomic_DNA.
DR   AlphaFoldDB; P55246; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          <1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..74
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012511"
FT   PEPTIDE         16..25
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012512"
FT   PEPTIDE         29..74
FT                   /note="GnRH-associated peptide 3"
FT                   /id="PRO_0000012513"
FT   MOD_RES         16
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   MOD_RES         25
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   NON_TER         1
SQ   SEQUENCE   74 AA;  8254 MW;  BD63C46D8228EF84 CRC64;
     VQVVVLALVA QVTLSQHWSY GWLPGGKRSV GELEATIKMM DTGGVVVLPE ETSAHVSERL
     RPYDVILKKW MPHK