ID   GON3_ONCNE              Reviewed;          82 AA.
AC   P69109; P35629; P51920;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Oncorhynchus nerka (Sockeye salmon) (Salmo nerka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8023;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=8674859; DOI=10.1016/0303-7207(95)03675-w;
RA   Coe I.R., von Schalburg K.R., Sherwood N.M.;
RT   "Characterization of the pacific salmon gonadotropin-releasing hormone
RT   gene, copy number and transcription start site.";
RL   Mol. Cell. Endocrinol. 115:113-122(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLN-81.
RC   STRAIN=Nikko; TISSUE=Brain;
RX   PubMed=8546809; DOI=10.1677/jme.0.0150001;
RA   Ashihara M., Suzuki M., Kubokawa K., Aida K., Urano A.;
RT   "Two differing precursor genes for the salmon-type gonadotropin-releasing
RT   hormone exist in salmonids.";
RL   J. Mol. Endocrinol. 15:1-9(1995).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; X91408; CAA62751.1; -; Genomic_DNA.
DR   EMBL; D31869; BAA06667.1; -; mRNA.
DR   AlphaFoldDB; P69109; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..82
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012514"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012515"
FT   PEPTIDE         37..82
FT                   /note="GnRH-associated peptide 3"
FT                   /id="PRO_0000012516"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   VARIANT         81
FT                   /note="H -> Q"
FT                   /evidence="ECO:0000269|PubMed:8546809"
SQ   SEQUENCE   82 AA;  9143 MW;  8053F4E44A765408 CRC64;
     MDLSNRTVVQ VVVLALVAQV TLSQHWSYGW LPGGKRSVGE LEATIKMMDT GGVVALPEET
     SAHVSERLRP YDVILKKWMP HK