ID   GON3_ONCTS              Reviewed;          74 AA.
AC   Q92097;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor; Fragment;
GN   Name=gnrh3;
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Muscle;
RX   PubMed=1587389; DOI=10.1016/0303-7207(92)90027-4;
RA   Klungland H., Lorens J.B., Andersen O., Kisen G.O., Alestroem P.;
RT   "The Atlantic salmon prepro-gonadotropin releasing hormone gene and mRNA.";
RL   Mol. Cell. Endocrinol. 84:167-174(1992).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; X79711; CAA56150.1; -; Genomic_DNA.
DR   PIR; I51092; I51092.
DR   AlphaFoldDB; Q92097; -.
DR   Proteomes; UP000694402; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          <1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..74
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012517"
FT   PEPTIDE         16..25
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012518"
FT   PEPTIDE         29..74
FT                   /note="GnRH-associated peptide 3"
FT                   /id="PRO_0000012519"
FT   MOD_RES         16
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   MOD_RES         25
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P69105"
FT   NON_TER         1
SQ   SEQUENCE   74 AA;  8254 MW;  BEAF0B783F80EF84 CRC64;
     VRVVVLALVA QVTLSQHWSY GWLPGGKRSV GELEATIKMM DTGGVVALPE ETSAHVSERL
     RPYDVILKKW MPHK