ID   GON3_ORYLA              Reviewed;          90 AA.
AC   Q9DD49; Q8JIQ3;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   AltName: Full=Salmon-type gonadotropin-releasing hormone;
DE            Short=sGnRH;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000312|EMBL:BAB16302.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain {ECO:0000312|EMBL:BAB16301.1};
RX   PubMed=11006121; DOI=10.1006/bbrc.2000.3476;
RA   Okubo K., Amano M., Yoshiura Y., Suetake H., Aida K.;
RT   "A novel form of gonadotropin-releasing hormone in the medaka, Oryzias
RT   latipes.";
RL   Biochem. Biophys. Res. Commun. 276:298-303(2000).
RN   [2] {ECO:0000312|EMBL:BAC06425.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Himedaka {ECO:0000269|PubMed:12137956}, and
RC   HNI {ECO:0000312|EMBL:BAC06425.1};
RX   PubMed=12137956; DOI=10.1016/s0378-1119(02)00724-2;
RA   Okubo K., Mitani H., Naruse K., Kondo M., Shima A., Tanaka M., Asakawa S.,
RA   Shimizu N., Yoshiura Y., Aida K.;
RT   "Structural characterization of GnRH loci in the medaka genome.";
RL   Gene 293:181-189(2002).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC       {ECO:0000250|UniProtKB:P45653, ECO:0000255|RuleBase:RU000635}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P45653}.
CC   -!- TISSUE SPECIFICITY: Expressed in neuron cell bodies of the nucleus
CC       olfactoretinalis. {ECO:0000269|PubMed:11006121}.
CC   -!- MISCELLANEOUS: Teleost species possess three paralogous GnRHs: mdGnRH
CC       and cGnRH-II have been identified in tetrapods; sGnRH has no tetrapod
CC       ortholog and is thought to be a duplication of cGnRH-II.
CC       {ECO:0000303|PubMed:12137956}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000255|RuleBase:RU000635,
CC       ECO:0000305}.
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DR   EMBL; AB041331; BAB16301.1; -; mRNA.
DR   EMBL; AB041332; BAB16302.1; -; mRNA.
DR   EMBL; AB041335; BAC06418.1; -; Genomic_DNA.
DR   EMBL; AB074501; BAC06425.1; -; Genomic_DNA.
DR   PIR; JC7395; JC7395.
DR   RefSeq; NP_001098142.1; NM_001104672.1.
DR   AlphaFoldDB; Q9DD49; -.
DR   STRING; 8090.ENSORLP00000007327; -.
DR   GeneID; 100049220; -.
DR   KEGG; ola:100049220; -.
DR   CTD; 360141; -.
DR   eggNOG; ENOG502SB0W; Eukaryota.
DR   InParanoid; Q9DD49; -.
DR   OrthoDB; 1556205at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; ISS:UniProtKB.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..90
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012520"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012521"
FT   PEPTIDE         37..90
FT                   /note="GnRH-associated peptide 3"
FT                   /id="PRO_0000012522"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        17
FT                   /note="V -> M (in Ref. 2; BAC06425)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   90 AA;  10176 MW;  AE0B3DC9047475B9 CRC64;
     MDVSSKVVVQ VLLLALVVQV TLCQHWSYGW LPGGKRSVGE LEATIRMMGT GRVVSLPEDA
     SAQTQERLRQ YNLINDGSTY FDRKKRFMSQ