ID   GON3_PETMA              Reviewed;          10 AA.
AC   P30948;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   RecName: Full=Gonadoliberin-3;
DE   AltName: Full=Gonadoliberin III;
DE   AltName: Full=Gonadotropin-releasing hormone III;
DE            Short=GnRH-III;
DE   AltName: Full=Luliberin III;
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   GLY-10.
RC   TISSUE=Brain;
RX   PubMed=8440174; DOI=10.1210/endo.132.3.8440174;
RA   Sower S.A., Chiang Y.-C., Lovas S., Conlon J.M.;
RT   "Primary structure and biological activity of a third gonadotropin-
RT   releasing hormone from lamprey brain.";
RL   Endocrinology 132:1125-1131(1993).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates the
CC       secretion of both luteinizing and follicle-stimulating hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000043960"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:8440174"
FT   MOD_RES         10
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:8440174"
SQ   SEQUENCE   10 AA;  1277 MW;  284B36237AA1F5A3 CRC64;
     QHWSHDWKPG