ID   GON3_PORNO              Reviewed;          89 AA.
AC   P51922;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Porichthys notatus (Plainfin midshipman).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Batrachoidaria; Batrachoididae; Porichthys.
OX   NCBI_TaxID=45384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7657161; DOI=10.1006/gcen.1995.1088;
RA   Grober M.S., Myers T.R., Marchaterre M.A., Bass A.H., Myers D.A.;
RT   "Structure, localization, and molecular phylogeny of a GnRH cDNA from a
RT   paracanthopterygian fish, the plainfin midshipman (Porichthys notatus).";
RL   Gen. Comp. Endocrinol. 99:85-99(1995).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U41669; AAC59754.1; -; mRNA.
DR   EMBL; S79620; AAB35188.1; -; mRNA.
DR   AlphaFoldDB; P51922; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..89
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012526"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012527"
FT   PEPTIDE         37..89
FT                   /note="GnRH-associated peptide 3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000012528"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   89 AA;  10118 MW;  AED532789B9F1475 CRC64;
     MRPYNVIVVM VVLLALVLHA VLSQHWSYGW LPGGKRSVGE LEATIRMMGT GGVVSLPEET
     SAQTQERLRP YNIINDGGYF NRKKRFFHE