ID   GON3_RUTRU              Reviewed;          94 AA.
AC   Q92106;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Rutilus rutilus (Roach).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Leuciscidae; Leuciscinae; Rutilus.
OX   NCBI_TaxID=48668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Olfactory bulb;
RX   PubMed=9460654; DOI=10.1677/jme.0.0190337;
RA   Penlington M.C., Williams M.A., Sumpter J.P., Rand-Weaver M., Hoole D.,
RA   Arme C.;
RT   "Isolation and characterisation of mRNA encoding the salmon- and
RT   chicken- II type gonadotrophin-releasing hormones in the teleost fish
RT   Rutilus rutilus (Cyprinidae).";
RL   J. Mol. Endocrinol. 19:337-346(1997).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; U60667; AAB65821.1; -; mRNA.
DR   AlphaFoldDB; Q92106; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..94
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012529"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012530"
FT   PEPTIDE         37..94
FT                   /note="GnRH-associated peptide 3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000012531"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   94 AA;  10683 MW;  CB1ED2215AA4DC4D CRC64;
     MEWKGRVLVQ LLMLVCVLEV SLCQHWSYGW LPGGKRSVGE VEATIRMMDG GDTLLSIPAD
     TPMEQLSPIH IMNEVDAEGF PLKEQRFPNR RGRM