ID   GON3_SALTR              Reviewed;          82 AA.
AC   P45653;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1587389; DOI=10.1016/0303-7207(92)90027-4;
RA   Klungland H., Lorens J.B., Andersen O., Kisen G.O., Alestroem P.;
RT   "The Atlantic salmon prepro-gonadotropin releasing hormone gene and mRNA.";
RL   Mol. Cell. Endocrinol. 84:167-174(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Muscle;
RA   Klungland H., Anderson O., Alestroem P.;
RT   "The salmon gonadotrophin-releasing hormone encoding gene in salmonids.";
RL   Mol. Mar. Biol. Biotechnol. 1:420-425(1992).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; X79713; CAA56152.1; -; Genomic_DNA.
DR   PIR; I51365; I51365.
DR   AlphaFoldDB; P45653; -.
DR   Ensembl; ENSSTUT00000041895; ENSSTUP00000040072; ENSSTUG00000017052.
DR   GeneTree; ENSGT00390000009274; -.
DR   OMA; VILKKWM; -.
DR   Proteomes; UP000472277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..82
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012538"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012539"
FT   PEPTIDE         37..82
FT                   /note="GnRH-associated peptide 3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000012540"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   82 AA;  9191 MW;  8053E9534A765408 CRC64;
     MDLSNRTVVQ VVVLALVAQV TLSQHWSYGW LPGGKRSVGE LEATIKMMDT GGVVALPEET
     SAHFSERLRP YDVILKKWMP HK