ID   GON3_VERMO              Reviewed;          90 AA.
AC   Q8UW82;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Progonadoliberin-3;
DE   AltName: Full=Progonadoliberin III;
DE   AltName: Full=Salmon-type gonadotropin-releasing hormone;
DE            Short=sGnRH;
DE   Contains:
DE     RecName: Full=Gonadoliberin-3;
DE     AltName: Full=Gonadoliberin III;
DE     AltName: Full=Gonadotropin-releasing hormone III;
DE              Short=GnRH III;
DE     AltName: Full=Luliberin III;
DE     AltName: Full=Luteinizing hormone-releasing hormone III;
DE              Short=LH-RH III;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 3;
DE     AltName: Full=GnRH-associated peptide III;
DE   Flags: Precursor;
GN   Name=gnrh3;
OS   Verasper moseri (Barfin flounder).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae; Verasper.
OX   NCBI_TaxID=98923;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAB83982.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain {ECO:0000269|PubMed:12093120};
RX   PubMed=12093120; DOI=10.1016/s0016-6480(02)00008-4;
RA   Amano M., Takahashi A., Yamanome T., Okubo K., Aida K., Yamamori K.;
RT   "Molecular cloning of three cDNAs encoding different GnRHs in the brain of
RT   barfin flounder.";
RL   Gen. Comp. Endocrinol. 126:325-333(2002).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC       {ECO:0000255|RuleBase:RU000635}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|RuleBase:RU000635}.
CC   -!- TISSUE SPECIFICITY: Brain; ventromedial olfactory bulbs and terminal
CC       nerve ganglion. {ECO:0000269|PubMed:12093120}.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB066358; BAB83982.1; -; mRNA.
DR   AlphaFoldDB; Q8UW82; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; ISS:UniProtKB.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255, ECO:0000312|EMBL:BAB83982.1"
FT   CHAIN           24..90
FT                   /note="Progonadoliberin-3"
FT                   /id="PRO_0000012453"
FT   PEPTIDE         24..33
FT                   /note="Gonadoliberin-3"
FT                   /id="PRO_0000012454"
FT   PEPTIDE         37..90
FT                   /note="GnRH-associated peptide 3"
FT                   /id="PRO_0000012455"
FT   REGION          57..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P20367"
FT   MOD_RES         33
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   90 AA;  10090 MW;  5BFD01586CEABC9D CRC64;
     MEASSRLVVQ VLVLMLVVQV ALSQHWSYGW LPGGKRSVGE LEATIRMMGT GGVVSLPEEA
     SAQTQERPRP YNVIDDGSRH FHRKKRFPDN