GON4L_MOUSE
ID GON4L_MOUSE Reviewed; 2260 AA.
AC Q9DB00; E9Q5N3; Q80TB4; Q91YI9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=GON-4-like protein;
DE AltName: Full=GON-4 homolog;
GN Name=Gon4l; Synonyms=Gon4, Kiaa1606;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-168.
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-2260.
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1531-2260.
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=20530203; DOI=10.1084/jem.20100147;
RA Lu P., Hankel I.L., Knisz J., Marquardt A., Chiang M.Y., Grosse J.,
RA Constien R., Meyer T., Schroeder A., Zeitlmann L., Al-Alem U.,
RA Friedman A.D., Elliott E.I., Meyerholz D.K., Waldschmidt T.J.,
RA Rothman P.B., Colgan J.D.;
RT "The Justy mutation identifies Gon4-like as a gene that is essential for B
RT lymphopoiesis.";
RL J. Exp. Med. 207:1359-1367(2010).
RN [7]
RP FUNCTION, IDENTIFICATION IN A COMPLEX WITH YY1; SIN3A AND HDAC1, AND
RP SUBCELLULAR LOCATION.
RX PubMed=21454521; DOI=10.1074/jbc.m110.133603;
RA Lu P., Hankel I.L., Hostager B.S., Swartzendruber J.A., Friedman A.D.,
RA Brenton J.L., Rothman P.B., Colgan J.D.;
RT "The developmental regulator protein Gon4l associates with protein YY1, co-
RT repressor Sin3a, and histone deacetylase 1 and mediates transcriptional
RT repression.";
RL J. Biol. Chem. 286:18311-18319(2011).
RN [8]
RP STRUCTURE BY NMR OF 2148-2230.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of mouse hypothetical gene (2610100B20Rik) product
RT homologous to Myb DNA-binding domain.";
RL Submitted (JUN-2004) to the PDB data bank.
CC -!- FUNCTION: Has transcriptional repressor activity, probably as part of a
CC complex with YY1, SIN3A AND HDAC1 (PubMed:21454521). Required for B
CC cell lymphopoiesis (PubMed:20530203). {ECO:0000269|PubMed:20530203,
CC ECO:0000269|PubMed:21454521}.
CC -!- SUBUNIT: Found in a complex with YY1, SIN3A and HDAC1.
CC {ECO:0000269|PubMed:21454521}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810,
CC ECO:0000269|PubMed:21454521}.
CC -!- TISSUE SPECIFICITY: Expressed in thymus. Specifically expressed in B
CC cells and their precursors (at protein level). Also detected in brain,
CC heart, spleen and bone marrow. {ECO:0000269|PubMed:20530203}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16616.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB23992.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
CC Sequence=BAC65813.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC127377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK005385; BAB23992.1; ALT_TERM; mRNA.
DR EMBL; AK122531; BAC65813.1; ALT_INIT; mRNA.
DR EMBL; BC016616; AAH16616.1; ALT_INIT; mRNA.
DR RefSeq; XP_017175282.1; XM_017319793.1.
DR PDB; 1UG2; NMR; -; A=2148-2228.
DR PDBsum; 1UG2; -.
DR AlphaFoldDB; Q9DB00; -.
DR SMR; Q9DB00; -.
DR BioGRID; 217912; 4.
DR CORUM; Q9DB00; -.
DR STRING; 10090.ENSMUSP00000088461; -.
DR iPTMnet; Q9DB00; -.
DR PhosphoSitePlus; Q9DB00; -.
DR EPD; Q9DB00; -.
DR jPOST; Q9DB00; -.
DR MaxQB; Q9DB00; -.
DR PaxDb; Q9DB00; -.
DR PRIDE; Q9DB00; -.
DR ProteomicsDB; 271251; -.
DR Ensembl; ENSMUST00000081695; ENSMUSP00000080397; ENSMUSG00000054199.
DR GeneID; 76022; -.
DR UCSC; uc008pxb.1; mouse.
DR CTD; 54856; -.
DR MGI; MGI:1917579; Gon4l.
DR eggNOG; ENOG502QT2W; Eukaryota.
DR GeneTree; ENSGT00390000016256; -.
DR InParanoid; Q9DB00; -.
DR OrthoDB; 49443at2759; -.
DR BioGRID-ORCS; 76022; 10 hits in 73 CRISPR screens.
DR ChiTaRS; Gon4l; mouse.
DR EvolutionaryTrace; Q9DB00; -.
DR PRO; PR:Q9DB00; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9DB00; protein.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0031011; C:Ino80 complex; ISO:MGI.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
DR GO; GO:0030183; P:B cell differentiation; IMP:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.20.1160.11; -; 1.
DR InterPro; IPR033277; GON-4-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR16088:SF11; PTHR16088:SF11; 2.
DR Pfam; PF02671; PAH; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47762; SSF47762; 2.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51477; PAH; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..2260
FT /note="GON-4-like protein"
FT /id="PRO_0000197110"
FT DOMAIN 1648..1720
FT /note="PAH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT DOMAIN 1730..1801
FT /note="PAH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT DOMAIN 2167..2220
FT /note="Myb-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..1364
FT /note="Required for interaction with YY1, SIN3A AND HDAC1,
FT and transcriptional repression activity"
FT /evidence="ECO:0000269|PubMed:21454521"
FT REGION 613..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1367..1625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1835..1935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1949..1974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2026..2088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2134..2162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2227..2260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..392
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..572
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1368..1383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1502
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1536..1560
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1837..1870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1896..1910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 347
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3T8J9"
FT MOD_RES 784
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1925
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3T8J9"
FT MOD_RES 1998
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3T8J9"
FT CONFLICT 259
FT /note="P -> L (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 734
FT /note="I -> V (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1080
FT /note="A -> S (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1341
FT /note="S -> P (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1354
FT /note="Q -> E (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1364
FT /note="F -> L (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1392
FT /note="S -> R (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1407
FT /note="M -> T (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1438
FT /note="L -> P (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 1458
FT /note="A -> V (in Ref. 3; BAC65813)"
FT /evidence="ECO:0000305"
FT CONFLICT 2069
FT /note="S -> P (in Ref. 3; BAC65813 and 4; AAH16616)"
FT /evidence="ECO:0000305"
FT STRAND 2173..2175
FT /evidence="ECO:0007829|PDB:1UG2"
FT HELIX 2177..2189
FT /evidence="ECO:0007829|PDB:1UG2"
FT TURN 2194..2196
FT /evidence="ECO:0007829|PDB:1UG2"
FT HELIX 2197..2204
FT /evidence="ECO:0007829|PDB:1UG2"
FT HELIX 2209..2225
FT /evidence="ECO:0007829|PDB:1UG2"
FT STRAND 2227..2229
FT /evidence="ECO:0007829|PDB:1UG2"
SQ SEQUENCE 2260 AA; 248742 MW; BB0F605666D642C6 CRC64;
MLPCKKRRLS VTESSQQQDD QEGDDLDLEA AVKPDTDQLP DSASESLSWG QSQDSAVCPE
GLSMQDGDDQ LRAEGLSLNS KMLAQHVNLA VLEAVDVAVS QEIPLPSLES SHSLPVHVDK
GRLQVSASKK GKRVVFTPGQ VTREDRGDHP VPEEPPSGEP AEEAKTEGGE LELRSDGEVP
LLSSSSQSAK PGAQPRKSVQ PDGSAFPQDK PLGPLVRQAE EEMEDGGLFI PTEEQDSEES
DKKKKTKKGT KRKRDGKGPE QGTMVYDPKL DDMLDRTLED GAKQHNLTAV NVRNILHEVI
TNEHVVAMMK AAISETEDMP LFEPKMTRSK LKEVVEKGVV IPTWNISPIK KASEIKQPPQ
FVDIHLEEDD SSDEEYSPDE EEEDETAEES LLESDVESTA SSPRGVKRSR LRLSSEVAET
DEESGMLSEV EKAATPALRH ISAEVVPMGP PPPPKPKQSR DSVFMEKLDA VDEELASSPV
CMDSFQPMED SLIAFRTRSK MPLKDVPLGQ LEAELQAPDI TPDMYDPNTA DDEDWKQWLG
GLINDDVENE DEADDDDDPE YNFLEDLDEP DTEDFRTDRA VRITKKEVNG LMEELFETVQ
SVVPSKFQDE MGFSNMEDDG PEEEERATES RPSFNTPQAL RFEEPLANLL NERHRTVKEL
LEQLKMKKPS VRQQPEVEKL KPQEEAAHQT LVLDPAQRSR LQQQMQQHVQ LLTQIYLLTT
SNPNLSSEAS TTRIFLKELG TFAENSIALH QQFNPRFQTL FQPCNWMGAM RLIEDFTQVS
IDCSPHKTAK KTASEFPCLP KQVAWILATN KVFMYPELLP ICSLKANNPR DKTIFTKAED
NLLALGLKHF EGTEFPKPLI SKYLVTCKTA HQLTVRIKNL NLNRAPNNVI KFYKKTKQLP
VLVRCCEEIQ PHQWKPPFEK EEHRLPFWLK ASLQSIQDEL RNISEGATEG GSVTTATESS
TDQHLQKASP ALGDEPQYPL LLPKGVVLKL KPGSKRFSRK AWRQKRPLVQ KPLLIQPSPS
VQPVFNPGKM ATWPTQSEVP PSNTVVQIPH LIQPAAVLQT LPGFPSVGVR GEDGFESPTA
LPAMPCGSEA RTTFPLSETQ SAPPSCSAPK LMLPSLAPSK FRKPYVRRKP TRRKGAKVSP
CVKPAPIIHP TPVIFTVPAT TVKVVSIGGG CNMIQPVSAA VAPSPQTIPI TTLLVNPTTF
PCSLNQPLVA SSISPLIVSS NPLTLPVTSI PEDKAQVKLD VAEGKNAPQN PESKLKPQEL
TPLCTTVFSK EEPKSWHSSA DTGSQEAFSE SSACSWAVVK TESQEGSSEK SACGWTVVKT
EDGGHAVEPL PQNLQDSLSS SSKDLLNMVK MEAQDCMVEI SSNFPKQDIG EEVKEECSME
LDSESPQEKP SSASEMSKQT VLQREDMQAA KSPSVPQDAA AEGRTSSHAS RGLPKSTLSS
MGQGGGLSGP PGKLEDSANA DGQSVGTPAG PDTGGEKDGP EEEEEEDFDD LTQDEEDELS
SASEESVLSV PELQETMEKL TWLASERRMS QEGESEEENS QEENSEPEEE EEEEAEGMET
LQKEDEVNDE AVGDAAKKPP STLASPQTAP EIETSIAPAG ESIKAAGKGR SSHRARNKRG
SRARASKDTS KLLLLYDEDI LDRDPLREQK DLAFAQAYLT RVREALQHTP GKYEDFLQII
YEFESSTQMH SAVDLFKSLQ TLLQDWPQLL KDFAAFLLPE QALSCGLFEE QQAFEKSRKF
LRQLEICFAE NPSHHQKIIK VLQGCADCLP QDIAELKTQM WQLLRGHDHL QDEFSIFFDH
LRPAASRMGD FEEINWTEEK EYEFDGFEEV ILPDVEEDEE PAKVSTASKS KRRKEIGVQH
QDKDTEWPEA AKDCSCSCHE GGPESKLKKS KRRNCHCSSK VCDSKPYKSK EPPELVGSGP
LHEASTVPGS KEAGQGKDML EEEILEEQEN MEVTQSKTAR TTRKGEAPAP GSTIGSTLLC
PAEVTPMELL LEGPALCSAE TPRLPPQTGA VVCSVRRNQA GPEVVSCLST SSLPPEEGED
QRAAANSETI APHREASETE RLPETVEHSA PLPSPVSTRT RDTGRRHICG KAGSQSWLIE
SRAEAEAAHV AAPICEKSSG ARASEAAPKT AREVLAEDSG TQGMGPEGAL PKASEATVCA
NNSKVSSTGE KVVLWTREAD RVILTMCQEQ GAQPHTFSVI SQQLGNKTPV EVSHRFRELM
QLFHTACEAS SEDEDDATST SNADQLSDHG DLLSEEELDE
