ID   GON7_CANAL              Reviewed;         121 AA.
AC   Q59W04; A0A1D8PCR7; Q59VX0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=EKC/KEOPS complex subunit GON7;
GN   Name=GON7; OrderedLocusNames=CAALFM_C102310CA;
GN   ORFNames=CaO19.11172, CaO19.3688;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC       formation of a threonylcarbamoyl group on adenosine at position 37
CC       (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC       is probably involved in the transfer of the threonylcarbamoyl moiety of
CC       threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely
CC       plays a supporting role to the catalytic subunit KAE1 in the complex.
CC       The EKC/KEOPS complex also promotes both telomere uncapping and
CC       telomere elongation. The complex is required for efficient recruitment
CC       of transcriptional coactivators (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least BUD32,
CC       CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GON7 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017623; AOW25916.1; -; Genomic_DNA.
DR   RefSeq; XP_713782.1; XM_708689.1.
DR   AlphaFoldDB; Q59W04; -.
DR   SMR; Q59W04; -.
DR   STRING; 237561.Q59W04; -.
DR   PRIDE; Q59W04; -.
DR   GeneID; 3644570; -.
DR   KEGG; cal:CAALFM_C102310CA; -.
DR   CGD; CAL0000189656; orf19.11172.
DR   VEuPathDB; FungiDB:C1_02310C_A; -.
DR   eggNOG; ENOG502S429; Eukaryota.
DR   HOGENOM; CLU_151420_0_0_1; -.
DR   InParanoid; Q59W04; -.
DR   OMA; QINVYLT; -.
DR   OrthoDB; 1575178at2759; -.
DR   PRO; PR:Q59W04; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR014849; EKC/KEOPS_Gon7.
DR   Pfam; PF08738; Gon7; 1.
PE   3: Inferred from homology;
KW   Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW   Transcription; Transcription regulation; tRNA processing.
FT   CHAIN           1..121
FT                   /note="EKC/KEOPS complex subunit GON7"
FT                   /id="PRO_0000278920"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   121 AA;  13421 MW;  347CBB964AAA4050 CRC64;
     MKLTPTAIYT APDIDSPKHF HLSKNEDHST NGKTTQISDI VIKAGGEDRD KPSDHKDTPL
     GNLRAELTTL QDHLNIFLTE RMKLEKLKNG GGGGGGDNNK SNEQDLERRI LDEGVEEEEI
     E