GON7_MOUSE
ID GON7_MOUSE Reviewed; 98 AA.
AC P0C8B4;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=EKC/KEOPS complex subunit GON7 {ECO:0000305};
GN Name=Gon7 {ECO:0000312|MGI:MGI:4845848};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 plays a
CC supporting role to the catalytic subunit OSGEP in the complex.
CC {ECO:0000250|UniProtKB:Q9BXV9}.
CC -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least GON7,
CC TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
CC {ECO:0000250|UniProtKB:Q9BXV9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BXV9}.
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DR EMBL; AK010878; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS49148.1; -.
DR RefSeq; NP_001136410.1; NM_001142938.1.
DR AlphaFoldDB; P0C8B4; -.
DR SMR; P0C8B4; -.
DR BioGRID; 950218; 3.
DR STRING; 10090.ENSMUSP00000136425; -.
DR PhosphoSitePlus; P0C8B4; -.
DR EPD; P0C8B4; -.
DR MaxQB; P0C8B4; -.
DR PaxDb; P0C8B4; -.
DR PRIDE; P0C8B4; -.
DR ProteomicsDB; 271252; -.
DR Ensembl; ENSMUST00000173969; ENSMUSP00000136425; ENSMUSG00000091931.
DR GeneID; 100233175; -.
DR KEGG; mmu:100233175; -.
DR UCSC; uc011yqr.1; mouse.
DR CTD; 84520; -.
DR MGI; MGI:4845848; Gon7.
DR VEuPathDB; HostDB:ENSMUSG00000091931; -.
DR eggNOG; ENOG502SW4V; Eukaryota.
DR GeneTree; ENSGT00490000044274; -.
DR HOGENOM; CLU_180906_0_0_1; -.
DR InParanoid; P0C8B4; -.
DR OMA; PCEAPGD; -.
DR OrthoDB; 1575198at2759; -.
DR PhylomeDB; P0C8B4; -.
DR BioGRID-ORCS; 100233175; 2 hits in 48 CRISPR screens.
DR PRO; PR:P0C8B4; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P0C8B4; protein.
DR Bgee; ENSMUSG00000091931; Expressed in peripheral nervous system and 74 other tissues.
DR ExpressionAtlas; P0C8B4; baseline and differential.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0000408; C:EKC/KEOPS complex; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; ISS:UniProtKB.
DR InterPro; IPR027893; GON7_meta.
DR PANTHER; PTHR37363; PTHR37363; 1.
DR Pfam; PF15387; DUF4611; 1.
PE 3: Inferred from homology;
KW Acetylation; Nucleus; Reference proteome.
FT CHAIN 1..98
FT /note="EKC/KEOPS complex subunit GON7"
FT /id="PRO_0000352801"
FT REGION 55..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BXV9"
SQ SEQUENCE 98 AA; 10346 MW; 2FF95CD74FE44F5B CRC64;
MELSGEYVGC DGEPQRLRVS CEASGDADPL QSLSAGVVRM KELVAEFFGT LVEQDAQGLA
EDPDDALDGD DEDDAEDENN SGRTNSDGPS AKRPKPAS
