ID   GON7_PIG                Reviewed;         100 AA.
AC   P0C8B5;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=EKC/KEOPS complex subunit GON7 {ECO:0000305};
GN   Name=GON7 {ECO:0000250|UniProtKB:Q9BXV9};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=17407547; DOI=10.1186/gb-2007-8-4-r45;
RA   Gorodkin J., Cirera S., Hedegaard J., Gilchrist M.J., Panitz F.,
RA   Jorgensen C.B., Scheibye-Knudsen K., Arvin T., Lumholdt S., Sawera M.,
RA   Green T., Nielsen B.J., Havgaard J.H., Rosenkilde C., Wang J., Li H.,
RA   Li R., Liu B., Hu S., Dong W., Li W., Yu J., Wang J., Staerfeldt H.H.,
RA   Wernersson R., Madsen L.B., Thomsen B., Hornshoj H., Bujie Z., Wang X.,
RA   Wang X., Bolund L., Brunak S., Yang H., Bendixen C., Fredholm M.;
RT   "Porcine transcriptome analysis based on 97 non-normalized cDNA libraries
RT   and assembly of 1,021,891 expressed sequence tags.";
RL   Genome Biol. 8:R45.1-R45.16(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-100.
RX   PubMed=15679890; DOI=10.1186/1741-7007-3-2;
RA   Jorgensen F.G., Hobolth A., Hornshoj H., Bendixen C., Fredholm M.,
RA   Schierup M.H.;
RT   "Comparative analysis of protein coding sequences from human, mouse and the
RT   domesticated pig.";
RL   BMC Biol. 3:2-2(2005).
CC   -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC       formation of a threonylcarbamoyl group on adenosine at position 37
CC       (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC       is probably involved in the transfer of the threonylcarbamoyl moiety of
CC       threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 plays a
CC       supporting role to the catalytic subunit OSGEP in the complex.
CC       {ECO:0000250|UniProtKB:Q9BXV9}.
CC   -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least GON7,
CC       TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
CC       {ECO:0000250|UniProtKB:Q9BXV9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BXV9}.
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DR   EMBL; EW673700; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AY610397; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001161062.1; NM_001167590.1.
DR   AlphaFoldDB; P0C8B5; -.
DR   SMR; P0C8B5; -.
DR   STRING; 9823.ENSSSCP00000002661; -.
DR   PaxDb; P0C8B5; -.
DR   PeptideAtlas; P0C8B5; -.
DR   Ensembl; ENSSSCT00015020297; ENSSSCP00015007950; ENSSSCG00015015343.
DR   Ensembl; ENSSSCT00025025022; ENSSSCP00025010567; ENSSSCG00025018455.
DR   Ensembl; ENSSSCT00035044159; ENSSSCP00035017693; ENSSSCG00035033322.
DR   Ensembl; ENSSSCT00040084535; ENSSSCP00040036887; ENSSSCG00040062096.
DR   Ensembl; ENSSSCT00050069516; ENSSSCP00050029875; ENSSSCG00050051064.
DR   Ensembl; ENSSSCT00060069083; ENSSSCP00060029720; ENSSSCG00060050784.
DR   Ensembl; ENSSSCT00065072527; ENSSSCP00065031598; ENSSSCG00065052972.
DR   Ensembl; ENSSSCT00070003525; ENSSSCP00070002918; ENSSSCG00070001890.
DR   GeneID; 100155082; -.
DR   KEGG; ssc:100155082; -.
DR   CTD; 84520; -.
DR   eggNOG; ENOG502SW4V; Eukaryota.
DR   HOGENOM; CLU_180906_0_0_1; -.
DR   InParanoid; P0C8B5; -.
DR   OMA; PCEAPGD; -.
DR   OrthoDB; 1575198at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 7.
DR   Genevisible; P0C8B5; SS.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000408; C:EKC/KEOPS complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; ISS:UniProtKB.
DR   InterPro; IPR027893; GON7_meta.
DR   PANTHER; PTHR37363; PTHR37363; 1.
DR   Pfam; PF15387; DUF4611; 1.
PE   3: Inferred from homology;
KW   Acetylation; Nucleus; Reference proteome.
FT   CHAIN           1..100
FT                   /note="EKC/KEOPS complex subunit GON7"
FT                   /id="PRO_0000352802"
FT   REGION          50..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BXV9"
SQ   SEQUENCE   100 AA;  10775 MW;  C429C7F6CF63FAC0 CRC64;
     MELLGEYVGQ DGQRQRLRVP CEAPGNADHF QGLLSGVARM KELVAELFGS PVQGEAQDRV
     AAAPEEALDG DDEDDAEDEN NIDNRTNSDG PTAKRPKPPS