ID   GON7_SCHPO              Reviewed;          73 AA.
AC   A6X972;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=EKC/KEOPS complex subunit gon7;
GN   Name=gon7; ORFNames=SPAC6B12.18;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC       formation of a threonylcarbamoyl group on adenosine at position 37
CC       (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC       is probably involved in the transfer of the threonylcarbamoyl moiety of
CC       threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Gon7 likely
CC       plays a supporting role to the catalytic subunit pgp2 in the complex.
CC       The EKC/KEOPS complex also promotes both telomere uncapping and
CC       telomere elongation. The complex is required for efficient recruitment
CC       of transcriptional coactivators (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least
CC       SPAP27G11.07c/BUD32, cgi121, gon7, pgp2 and SPAC4H3.13/PCC1; the whole
CC       complex dimerizes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GON7 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAO77639.1; -; Genomic_DNA.
DR   RefSeq; XP_001713066.1; XM_001713014.2.
DR   AlphaFoldDB; A6X972; -.
DR   SMR; A6X972; -.
DR   BioGRID; 858027; 5.
DR   STRING; 4896.SPAC6B12.18.1; -.
DR   MaxQB; A6X972; -.
DR   PaxDb; A6X972; -.
DR   EnsemblFungi; SPAC6B12.18.1; SPAC6B12.18.1:pep; SPAC6B12.18.
DR   PomBase; SPAC6B12.18; gon7.
DR   VEuPathDB; FungiDB:SPAC6B12.18; -.
DR   HOGENOM; CLU_201359_0_0_1; -.
DR   OMA; DEQPIML; -.
DR   PRO; PR:A6X972; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0000408; C:EKC/KEOPS complex; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IC:PomBase.
PE   3: Inferred from homology;
KW   Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW   Transcription; Transcription regulation; tRNA processing.
FT   CHAIN           1..73
FT                   /note="EKC/KEOPS complex subunit gon7"
FT                   /id="PRO_0000303984"
SQ   SEQUENCE   73 AA;  8569 MW;  B7B9268CB9A6A8B7 CRC64;
     MNNLELTYKC ETDTTRPFLK SLPVGFEPVE VDDYYISLKE QVRAMQDHCN EEFTKKMQTE
     GKNDVPEEKP IIL