ID   GON8_RANDY              Reviewed;          90 AA.
AC   Q9IAU2;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Trp-8 progonadoliberin;
DE   Contains:
DE     RecName: Full=Trp-8 gonadoliberin;
DE     AltName: Full=LH-RH;
DE     AltName: Full=Luliberin;
DE     AltName: Full=Trp-8 gonadotropin-releasing hormone;
DE              Short=[Trp8]-GnRH;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide I;
DE   Flags: Precursor;
OS   Rana dybowskii (Dybovsky's frog) (Korean brown frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=71582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=11026571; DOI=10.1016/s0303-7207(00)00221-5;
RA   Yoo M.S., Kang H.M., Choi H.S., Kim J.W., Troskie B.E., Millar R.P.,
RA   Kwon H.B.;
RT   "Molecular cloning, distribution and pharmacological characterization of a
RT   novel gonadotropin-releasing hormone (Trp8 GnRH) in frog brain.";
RL   Mol. Cell. Endocrinol. 164:197-204(2000).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in forebrain but not in testis, ovary,
CC       kidney and liver.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF139911; AAF44343.1; -; mRNA.
DR   AlphaFoldDB; Q9IAU2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IEA:InterPro.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin.
DR   InterPro; IPR004079; Gonadoliberin_I_precursor.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   PRINTS; PR01541; GONADOLIBRNI.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..24
FT   CHAIN           25..90
FT                   /note="Trp-8 progonadoliberin"
FT                   /id="PRO_0000012550"
FT   PEPTIDE         25..34
FT                   /note="Trp-8 gonadoliberin"
FT                   /id="PRO_0000012551"
FT   PEPTIDE         38..86
FT                   /note="GnRH-associated peptide I"
FT                   /id="PRO_0000012552"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         34
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   90 AA;  10368 MW;  C3D573E78B52ABFA CRC64;
     MSRHVTVVLL LAVVLLLSSH MSHGQHWSYG LWPGGKREVE GLQESYSEVP NEVSFTDPQH
     FERSIPQNRI SLVREALMNW LEGENTRKKI