ID   GONL_SQUAC              Reviewed;          10 AA.
AC   P27429;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   29-SEP-2021, entry version 55.
DE   RecName: Full=Gonadoliberin;
DE   AltName: Full=Gonadotropin-releasing hormone;
DE            Short=GnRH;
DE   AltName: Full=LH-RH;
DE   AltName: Full=Luliberin;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   GLY-10.
RC   TISSUE=Brain;
RX   PubMed=1631133; DOI=10.1073/pnas.89.14.6373;
RA   Lovejoy D.A., Fischer W.H., Ngamvongchon S., Craig A.G., Nahorniak C.S.,
RA   Peter R.E., Rivier J.E., Sherwood N.M.;
RT   "Distinct sequence of gonadotropin-releasing hormone (GnRH) in dogfish
RT   brain provides insight into GnRH evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:6373-6377(1992).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   PIR; A46030; A46030.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..10
FT                   /note="Gonadoliberin"
FT                   /id="PRO_0000043958"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:1631133"
FT   MOD_RES         10
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:1631133"
SQ   SEQUENCE   10 AA;  1204 MW;  284B32337871F5A3 CRC64;
     QHWSHGWLPG