GONS2_ARATH
ID GONS2_ARATH Reviewed; 375 AA.
AC Q84L09; Q9LNU8;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=GDP-mannose transporter GONST2 {ECO:0000303|PubMed:15480787};
DE AltName: Full=Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 2 {ECO:0000303|PubMed:15480787};
GN Name=GONST2 {ECO:0000312|EMBL:CAD83086.1};
GN OrderedLocusNames=At1g07290 {ECO:0000312|Araport:AT1G07290};
GN ORFNames=F22G5.37 {ECO:0000312|EMBL:AAF79561.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=15480787; DOI=10.1007/s00438-004-1071-z;
RA Handford M.G., Sicilia F., Brandizzi F., Chung J.H., Dupree P.;
RT "Arabidopsis thaliana expresses multiple Golgi-localised nucleotide-sugar
RT transporters related to GONST1.";
RL Mol. Genet. Genomics 272:397-410(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=23695979; DOI=10.1105/tpc.113.111500;
RA Mortimer J.C., Yu X., Albrecht S., Sicilia F., Huichalaf M., Ampuero D.,
RA Michaelson L.V., Murphy A.M., Matsunaga T., Kurz S., Stephens E.,
RA Baldwin T.C., Ishii T., Napier J.A., Weber A.P., Handford M.G., Dupree P.;
RT "Abnormal glycosphingolipid mannosylation triggers salicylic acid-mediated
RT responses in Arabidopsis.";
RL Plant Cell 25:1881-1894(2013).
RN [5]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=27381418; DOI=10.1038/ncomms12119;
RA Rautengarten C., Ebert B., Liu L., Stonebloom S., Smith-Moritz A.M.,
RA Pauly M., Orellana A., Scheller H.V., Heazlewood J.L.;
RT "The Arabidopsis Golgi-localized GDP-L-fucose transporter is required for
RT plant development.";
RL Nat. Commun. 7:12119-12119(2016).
CC -!- FUNCTION: GDP-mannose transporter that may be involved in the import of
CC GDP-mannose from the cytoplasm into the Golgi lumen.
CC {ECO:0000269|PubMed:15480787}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:27381418}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in rosette leaves, stems, flowers and
CC siliques. {ECO:0000269|PubMed:15480787}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:23695979}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. GDP-
CC Mannose:GMP antiporter (GMA) (TC 2.A.7.13) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ551325; CAD83086.1; -; mRNA.
DR EMBL; AC022464; AAF79561.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q84L09; -.
DR SMR; Q84L09; -.
DR STRING; 3702.AT1G07290.1; -.
DR TCDB; 2.A.7.13.4; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; Q84L09; -.
DR PRIDE; Q84L09; -.
DR ProteomicsDB; 248445; -.
DR Araport; AT1G07290; -.
DR TAIR; locus:2025047; AT1G07290.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_738864_0_0_1; -.
DR InParanoid; Q84L09; -.
DR PhylomeDB; Q84L09; -.
DR PRO; PR:Q84L09; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q84L09; baseline and differential.
DR Genevisible; Q84L09; AT.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005458; F:GDP-mannose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:1990570; P:GDP-mannose transmembrane transport; IGI:TAIR.
DR GO; GO:0015780; P:nucleotide-sugar transmembrane transport; IGI:TAIR.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 2: Evidence at transcript level;
KW Antiport; Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..375
FT /note="GDP-mannose transporter GONST2"
FT /id="PRO_0000406121"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 375 AA; 41631 MW; 0598AF892FE77C73 CRC64;
MSAVKLEAIV CHEPDESELS HLSDNGSKTK NGVVFQLLDQ KSSEHRWFSE RFLRWRRRYL
PVDGDNRRDH GSVKQSGPLV SGAAYCISSC SMIILNKIVL SSYNFNAGVS LMLYQNLISC
LVVAVLDISG VVSVEKFNWK LIRVWMPVNV IFVGMLVSGM YSLKYINVAM VTILKNATNI
LTGIGEVYMF RKRQNNKVWA AMFMMIISAI SGGITDLTFD AVGYTWQLAN CFLTASYSLT
LRRVMDKAKQ STKSGSLNEV SMVLLNNLLS IPFGIILIIL LGEWRYVIST DVTKDSMFWV
VATASGFLGL AISFTSMWFL HQTGPTTYSL VGSLNKVPIS LAGLVLFNVP LSLPNLFSIL
FGLFAGVVFA RAKMS
