GONS3_ARATH
ID GONS3_ARATH Reviewed; 372 AA.
AC Q9S845;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=GDP-mannose transporter GONST3 {ECO:0000303|PubMed:15480787};
DE AltName: Full=Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 3 {ECO:0000303|PubMed:15480787};
GN Name=GONST3 {ECO:0000312|EMBL:CAD83087.1};
GN OrderedLocusNames=At1g76340 {ECO:0000312|Araport:AT1G76340};
GN ORFNames=F15M4.16 {ECO:0000312|EMBL:AAF17634.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=15480787; DOI=10.1007/s00438-004-1071-z;
RA Handford M.G., Sicilia F., Brandizzi F., Chung J.H., Dupree P.;
RT "Arabidopsis thaliana expresses multiple Golgi-localised nucleotide-sugar
RT transporters related to GONST1.";
RL Mol. Genet. Genomics 272:397-410(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia; TISSUE=Callus;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
CC -!- FUNCTION: GDP-mannose transporter that may be involved in the import of
CC GDP-mannose from the cytoplasm into the Golgi lumen.
CC {ECO:0000269|PubMed:15480787}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in rosette leaves, stems, flowers and
CC siliques. {ECO:0000269|PubMed:15480787}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. GDP-
CC Mannose:GMP antiporter (GMA) (TC 2.A.7.13) subfamily. {ECO:0000305}.
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DR EMBL; AJ551326; CAD83087.1; -; mRNA.
DR EMBL; AC009978; AAF17634.1; -; Genomic_DNA.
DR EMBL; AC012394; AAF16667.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35826.1; -; Genomic_DNA.
DR PIR; H96790; H96790.
DR RefSeq; NP_177760.1; NM_106283.3.
DR AlphaFoldDB; Q9S845; -.
DR SMR; Q9S845; -.
DR STRING; 3702.AT1G76340.1; -.
DR TCDB; 2.A.7.13.5; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; Q9S845; -.
DR PRIDE; Q9S845; -.
DR ProteomicsDB; 248446; -.
DR EnsemblPlants; AT1G76340.1; AT1G76340.1; AT1G76340.
DR GeneID; 843966; -.
DR Gramene; AT1G76340.1; AT1G76340.1; AT1G76340.
DR KEGG; ath:AT1G76340; -.
DR Araport; AT1G76340; -.
DR TAIR; locus:2014634; AT1G76340.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_045047_1_0_1; -.
DR InParanoid; Q9S845; -.
DR OMA; QFTIAAY; -.
DR OrthoDB; 870214at2759; -.
DR PhylomeDB; Q9S845; -.
DR PRO; PR:Q9S845; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9S845; baseline and differential.
DR Genevisible; Q9S845; AT.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005457; F:GDP-fucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005338; F:nucleotide-sugar transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015780; P:nucleotide-sugar transmembrane transport; IGI:TAIR.
DR InterPro; IPR029665; GONST3.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR PANTHER; PTHR11132:SF270; PTHR11132:SF270; 1.
DR Pfam; PF03151; TPT; 1.
PE 2: Evidence at transcript level;
KW Antiport; Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..372
FT /note="GDP-mannose transporter GONST3"
FT /id="PRO_0000406122"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 331..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 41740 MW; 03796AB0C75A9485 CRC64;
MSTNDEENGT VIEVKNVPEP SPETWYSVFL RQASVYGVAA GYCLSASLLS IINKWAIMKF
PYPGALTAMQ YFTSAAGVLL CAQMKLIEHD SLNLLTMWRF LPAAMIFYLS LFTNSELLLH
ANVDTFIVFR SAVPIFVAIG ETLFLHQPWP SVKTWGSLAT IFGGSLLYVF TDYQFTIAAY
SWALAYLVSM TIDFVYIKHV VMTIGLNTWG LVLYNNLEAL LLFPLELLIM GELKKIKHEI
TDETDWYSLQ VVLPVGLSCL FGLAISFFGF SCRRAISATG FTVLGIVNKL LTVVINLMVW
DKHSTFVGTL GLLVCMFGGV MYQQSTIKKP NATQEAKPQE QDEEQEKLLE MQENKESNSV
DIKETLKSEE KL
