GONS5_ARATH
ID GONS5_ARATH Reviewed; 341 AA.
AC Q9SFE9; A0ME82;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=GDP-mannose transporter GONST5;
DE AltName: Full=Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 5;
GN Name=GONST5; OrderedLocusNames=At1g21870; ORFNames=GT26F17.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=15480787; DOI=10.1007/s00438-004-1071-z;
RA Handford M.G., Sicilia F., Brandizzi F., Chung J.H., Dupree P.;
RT "Arabidopsis thaliana expresses multiple Golgi-localised nucleotide-sugar
RT transporters related to GONST1.";
RL Mol. Genet. Genomics 272:397-410(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia; TISSUE=Callus;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
CC -!- FUNCTION: GDP-mannose transporter that may be involved in the import of
CC GDP-mannose from the cytoplasm into the Golgi lumen.
CC {ECO:0000269|PubMed:15480787}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:15480787}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15480787}.
CC -!- TISSUE SPECIFICITY: Expressed in rosette leaves, flowers and siliques.
CC {ECO:0000269|PubMed:15480787}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. TPT (TC 2.A.7.9)
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28407.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ551328; CAD83089.1; -; mRNA.
DR EMBL; AC013482; AAF16530.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30166.1; -; Genomic_DNA.
DR EMBL; DQ446272; ABE65640.1; -; mRNA.
DR EMBL; DQ652850; ABK28407.1; ALT_SEQ; mRNA.
DR RefSeq; NP_173605.1; NM_102035.2.
DR AlphaFoldDB; Q9SFE9; -.
DR SMR; Q9SFE9; -.
DR BioGRID; 24028; 28.
DR IntAct; Q9SFE9; 28.
DR STRING; 3702.AT1G21870.1; -.
DR PaxDb; Q9SFE9; -.
DR PRIDE; Q9SFE9; -.
DR EnsemblPlants; AT1G21870.1; AT1G21870.1; AT1G21870.
DR GeneID; 838789; -.
DR Gramene; AT1G21870.1; AT1G21870.1; AT1G21870.
DR KEGG; ath:AT1G21870; -.
DR Araport; AT1G21870; -.
DR TAIR; locus:2201138; AT1G21870.
DR eggNOG; KOG1441; Eukaryota.
DR HOGENOM; CLU_022332_2_2_1; -.
DR InParanoid; Q9SFE9; -.
DR OMA; PWSALVI; -.
DR OrthoDB; 938634at2759; -.
DR PhylomeDB; Q9SFE9; -.
DR PRO; PR:Q9SFE9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SFE9; baseline and differential.
DR Genevisible; Q9SFE9; AT.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015780; P:nucleotide-sugar transmembrane transport; IGI:TAIR.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..341
FT /note="GDP-mannose transporter GONST5"
FT /id="PRO_0000406104"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 33..152
FT /note="EamA"
SQ SEQUENCE 341 AA; 38848 MW; C2BB40C25C98E78F CRC64;
MEEGSLWRQW TMFRSLLSIL QWWGFNVTVI IMNKWIFQKL DFKFPLSVSC VHFICSSIGA
YIVIKVLKLK PLIVVDPEDR WRRIFPMSFV FCINIVLGNI SLRYIPVSFM QTIKSLTPAT
TVVLQWLVWR KYFDWRIWAS LVPIVGGILL TSITELSFNV FGFCAALFGC LATSTKTILA
ESLLHGYKFD SINTVYYMAP FATMILGLPA FLLERNGILD WFEAHPSPWS ALIILFNSGV
LAFCLNFSIF YVIQSTTAVT FNVAGNLKVA VAVFVSWMIF RNPISPMNAV GCGITLVGCT
FYGYVRHMLS QQQPGTPRTP RTPRNKMELI PLVNDKLESK I
